Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | nitric oxide synthase 2, inducible | Starlite/ChEMBL | References |
Homo sapiens | nitric oxide synthase 1 (neuronal) | Starlite/ChEMBL | References |
Rattus norvegicus | Nitric-oxide synthase, brain | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0053 | 0.2407 | 0.2407 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0086 | 1 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0086 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0086 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0086 | 1 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0086 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0086 | 1 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0086 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0086 | 1 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0086 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0086 | 1 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0076 | 0.7743 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0086 | 1 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0086 | 1 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0086 | 1 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0086 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0076 | 0.7743 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0086 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0086 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0086 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0086 | 1 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0053 | 0.2407 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0086 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0043 | 0.0151 | 0.0151 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0086 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0086 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 24 nM | Inhibition of rat recombinant nNOS expressed in Escherichia coli by oxyhemoglobin NO assay | ChEMBL. | 26120733 |
Ki (binding) | = 55 nM | Inhibition of human recombinant nNOS expressed in Escherichia coli by oxyhemoglobin NO assay | ChEMBL. | 26120733 |
Ki (binding) | = 3669 nM | Inhibition of mouse recombinant iNOS expressed in Escherichia coli by oxyhemoglobin NO assay | ChEMBL. | 26120733 |
Ki (binding) | = 24950 nM | Inhibition of bovine recombinant eNOS expressed in Escherichia coli by oxyhemoglobin NO assay | ChEMBL. | 26120733 |
Tmax (ADMET) | = 0.25 hr | Tmax in BALB/c mouse plasma at 10 mg/kg, po | ChEMBL. | 26120733 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.