Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | acyl-protein thioesterase 12 (lysophospholipase III) | 0.0073 | 0.5 | 0.5 |
Trypanosoma brucei | lysophospholipase, putative | 0.0073 | 0.5 | 0.5 |
Toxoplasma gondii | phospholipase/carboxylesterase | 0.0073 | 0.5 | 0.5 |
Schistosoma mansoni | acyl-protein thioesterase 12 (lysophospholipase III) | 0.0073 | 0.5 | 0.5 |
Schistosoma mansoni | acyl-protein thioesterase 12 (lysophospholipase III) | 0.0073 | 0.5 | 0.5 |
Echinococcus multilocularis | acyl protein thioesterase 12 | 0.0073 | 0.5 | 0.5 |
Loa Loa (eye worm) | phospholipase/Carboxylesterase | 0.0073 | 0.5 | 0.5 |
Echinococcus multilocularis | acyl protein thioesterase 1 | 0.0073 | 0.5 | 0.5 |
Trypanosoma cruzi | lysophospholipase, putative | 0.0073 | 0.5 | 0.5 |
Echinococcus granulosus | acyl protein thioesterase 1 | 0.0073 | 0.5 | 0.5 |
Echinococcus granulosus | acyl protein thioesterase 12 | 0.0073 | 0.5 | 0.5 |
Chlamydia trachomatis | lysophospholipase esterase | 0.0073 | 0.5 | 0.5 |
Leishmania major | lysophospholipase, putative | 0.0073 | 0.5 | 0.5 |
Trypanosoma cruzi | lysophospholipase, putative | 0.0073 | 0.5 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | esterase | 0.0073 | 0.5 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.