Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1154 | 0.8616 | 0.8616 |
Onchocerca volvulus | Adenylate cyclase type 3 homolog | 0.1181 | 0.9 | 1 |
Echinococcus granulosus | adenylate cyclase type IX | 0.0806 | 0.3792 | 1 |
Echinococcus multilocularis | adenylate cyclase type IX | 0.0806 | 0.3792 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (ADMET) | = 52 ug ml-1 | Cytotoxicity against human DU145 cells assessed as growth inhibition after 48 hrs by SRB assay method | ChEMBL. | 26383125 |
IC50 (functional) | = 35.3 uM | Antileishmanial activity against promastigote form of Leishmania major MHOM/IL/81/BNI after 96 hrs by spectrofluorimetric micromethod | ChEMBL. | 26383125 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.