Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3268 | 0.3268 |
Onchocerca volvulus | Putative nachr subunit | 0.0164 | 0.3268 | 0.6005 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.371 | 0.371 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0164 | 0.3268 | 0.6005 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1611 | 0.1611 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0182 | 0.3799 | 0.5 |
Onchocerca volvulus | 0.024 | 0.5442 | 1 | |
Onchocerca volvulus | 0.0188 | 0.3955 | 0.7268 | |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.5442 | 0.5442 |
Onchocerca volvulus | 0.0106 | 0.1611 | 0.2959 | |
Schistosoma mansoni | calcium-activated potassium channel | 0.0379 | 0.9443 | 0.9443 |
Brugia malayi | hypothetical protein | 0.024 | 0.5442 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0134 | 0.2421 | 0.2421 |
Onchocerca volvulus | 0.0106 | 0.1611 | 0.2959 | |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0164 | 0.3268 | 0.3268 |
Echinococcus multilocularis | geminin | 0.0134 | 0.2421 | 0.2421 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.4298 | 0.4298 |
Schistosoma mansoni | hypothetical protein | 0.0134 | 0.2421 | 0.2421 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0165 | 0.3301 | 0.3301 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0164 | 0.3268 | 0.3268 |
Brugia malayi | Cation transporter family protein | 0.0106 | 0.1611 | 0.2959 |
Brugia malayi | Pre-SET motif family protein | 0.0165 | 0.3301 | 0.6066 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0164 | 0.3268 | 0.3268 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0164 | 0.3268 | 0.3268 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1611 | 0.1611 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0106 | 0.1611 | 0.1611 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0164 | 0.3268 | 0.3268 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0949 | 0.0949 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0164 | 0.3268 | 0.3268 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0106 | 0.1611 | 0.1611 |
Echinococcus granulosus | geminin | 0.0134 | 0.2421 | 0.2421 |
Trichomonas vaginalis | set domain proteins, putative | 0.0188 | 0.3955 | 0.5 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0164 | 0.3268 | 0.3268 |
Onchocerca volvulus | 0.0106 | 0.1611 | 0.2959 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 32 uM | Inhibition of MK2 (unknown origin) by scintillation proximity assay | ChEMBL. | 26403928 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.