Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0227 | 0.5381 | 0.5381 |
Brugia malayi | Cation transporter family protein | 0.0147 | 0.2652 | 0.2959 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0227 | 0.5381 | 0.5381 |
Schistosoma mansoni | hypothetical protein | 0.0187 | 0.3987 | 0.3987 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.2652 | 0.2652 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0227 | 0.5381 | 0.5381 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0147 | 0.2652 | 0.2652 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.1562 | 0.1562 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.3199 | 0.3199 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0253 | 0.6256 | 0.5 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0147 | 0.2652 | 0.2652 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0227 | 0.5381 | 0.5381 |
Onchocerca volvulus | Putative nachr subunit | 0.0227 | 0.5381 | 0.6005 |
Onchocerca volvulus | 0.0147 | 0.2652 | 0.2959 | |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0227 | 0.5381 | 0.5381 |
Brugia malayi | Pre-SET motif family protein | 0.0229 | 0.5436 | 0.6066 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0227 | 0.5381 | 0.6005 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.2652 | 0.2652 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0227 | 0.5381 | 0.5381 |
Brugia malayi | hypothetical protein | 0.0333 | 0.8961 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0261 | 0.6513 | 0.5 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0229 | 0.5436 | 0.5436 |
Onchocerca volvulus | 0.0333 | 0.8961 | 1 | |
Onchocerca volvulus | 0.0147 | 0.2652 | 0.2959 | |
Schistosoma mansoni | calcium-activated potassium channel | 0.0345 | 0.9397 | 0.9397 |
Onchocerca volvulus | 0.0147 | 0.2652 | 0.2959 | |
Schistosoma mansoni | hypothetical protein | 0.0187 | 0.3987 | 0.3987 |
Echinococcus multilocularis | geminin | 0.0187 | 0.3987 | 0.3987 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.8961 | 0.8961 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.3835 | 0.3835 |
Onchocerca volvulus | 0.0261 | 0.6513 | 0.7268 | |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0227 | 0.5381 | 0.5381 |
Echinococcus granulosus | geminin | 0.0187 | 0.3987 | 0.3987 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.5381 | 0.5381 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 50 uM | Cytotoxicity against human HCT15 cells measured after 2 days by MTT assay | ChEMBL. | 26334499 |
Inhibition (binding) | = 0 % | Inhibition of recombinant human topoisomerase 2alpha assessed as relaxation of supercoiled plasmid DNA pBR322 at 100 uM incubated for 30 mins by agarose gel electrophoresis | ChEMBL. | 26334499 |
Inhibition (binding) | = 36.3 % | Inhibition of recombinant human topoisomerase 1 assessed as relaxation of supercoiled plasmid DNA pBR322 at 20 uM incubated for 30 mins by agarose gel electrophoresis | ChEMBL. | 26334499 |
Inhibition (binding) | = 67.9 % | Inhibition of recombinant human topoisomerase 1 assessed as relaxation of supercoiled plasmid DNA pBR322 at 100 uM incubated for 30 mins by agarose gel electrophoresis | ChEMBL. | 26334499 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.