Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor X | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | egf-like domain protein | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0032 | 0.5 | 0.5 |
Echinococcus multilocularis | fibrillin 1 | 0.0032 | 0.5 | 0.5 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0032 | 0.5 | 0.5 |
Echinococcus granulosus | Tolloid protein 1 | 0.0032 | 0.5 | 0.5 |
Onchocerca volvulus | Arrow homolog | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0032 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0032 | 0.5 | 0.5 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0032 | 0.5 | 0.5 |
Echinococcus multilocularis | laminin | 0.0032 | 0.5 | 0.5 |
Echinococcus granulosus | laminin | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Brugia malayi | Fibulin-1 precursor | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1200 nM | BindingDB_Patents: Enzyme Inhibition Assay. The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-nitroaniline from the chromogenic substrate. The determinations were carried out in microtitre plates as follows.The test substances, in various concentrations, were dissolved in DMSO and incubated at 25 C. with human FXa (0.5 nmol/l dissolved in 50 mmol/l of tris buffer [C,C,C-tris(hydroxymethyl)-aminomethane], 150 mmol/l of NaCl, 0.1% BSA (bovine serum albumin), pH=8.3) for 10 minutes. Pure DMSO was used as control. The chromogenic substrate (150 umol 11 of Pefachrome FXa from Pentapharm) was then added. After an incubation time of 20 minutes at 25 C., the extinction at 405 nm was determined. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.