Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | MDM2 proto-oncogene, E3 ubiquitin protein ligase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glycine receptor subunit beta | 0.0125 | 0.0664 | 0.1747 |
Loa Loa (eye worm) | LGC-31 protein | 0.0125 | 0.0664 | 0.0664 |
Loa Loa (eye worm) | hypothetical protein | 0.0313 | 0.5607 | 0.5607 |
Echinococcus multilocularis | nAChR subunit | 0.0125 | 0.0664 | 0.1747 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0125 | 0.0664 | 0.1184 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0125 | 0.0664 | 0.1184 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0125 | 0.0664 | 0.1184 |
Schistosoma mansoni | nAChR subunit | 0.0125 | 0.0664 | 0.1747 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0125 | 0.0664 | 0.1747 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0125 | 0.0664 | 0.0664 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0116 | 0.0436 | 0.1148 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0125 | 0.0664 | 0.1747 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0244 | 0.3799 | 1 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0125 | 0.0664 | 0.1747 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0664 | 0.0664 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0116 | 0.0436 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0664 | 0.0664 |
Mycobacterium ulcerans | thymidylate synthase | 0.0244 | 0.3799 | 1 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0125 | 0.0664 | 0.1184 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0125 | 0.0664 | 0.1747 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0125 | 0.0664 | 0.1747 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0125 | 0.0664 | 0.1747 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0125 | 0.0664 | 0.1747 |
Onchocerca volvulus | 0.0244 | 0.3799 | 1 | |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0125 | 0.0664 | 0.0664 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0344 | 0.6415 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.01 | 0 | 0.5 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0125 | 0.0664 | 0.1184 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0664 | 0.0664 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0664 | 0.0664 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0344 | 0.6415 | 0.5 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0125 | 0.0664 | 0.1747 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0125 | 0.0664 | 0.1184 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0344 | 0.6415 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0244 | 0.3799 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0125 | 0.0664 | 0.1184 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0664 | 0.0664 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0125 | 0.0664 | 0.1747 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0664 | 0.0664 |
Schistosoma mansoni | nAChR subunit | 0.0125 | 0.0664 | 0.1747 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0125 | 0.0664 | 0.1747 |
Echinococcus granulosus | nAChR subunit | 0.0125 | 0.0664 | 0.1747 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0125 | 0.0664 | 0.1747 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0125 | 0.0664 | 0.1747 |
Brugia malayi | Cation transporter family protein | 0.0125 | 0.0664 | 0.1184 |
Loa Loa (eye worm) | ACC-1 protein | 0.0125 | 0.0664 | 0.0664 |
Loa Loa (eye worm) | thymidylate synthase | 0.0244 | 0.3799 | 0.3799 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0125 | 0.0664 | 0.1747 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0125 | 0.0664 | 0.0664 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0664 | 0.0664 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0125 | 0.0664 | 0.1184 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0125 | 0.0664 | 0.1747 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0664 | 0.0664 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0664 | 0.0664 |
Schistosoma mansoni | nAChR subunit | 0.0125 | 0.0664 | 0.1747 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0125 | 0.0664 | 0.1184 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0125 | 0.0664 | 0.1747 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0125 | 0.0664 | 0.1747 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0125 | 0.0664 | 0.1184 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0664 | 0.0664 |
Schistosoma mansoni | nAChR subunit | 0.0125 | 0.0664 | 0.1747 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0344 | 0.6415 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0344 | 0.6415 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0664 | 0.0664 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0125 | 0.0664 | 0.1747 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0125 | 0.0664 | 0.1747 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0125 | 0.0664 | 0.1184 |
Schistosoma mansoni | nAChR subunit | 0.0125 | 0.0664 | 0.1747 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0125 | 0.0664 | 0.1184 |
Echinococcus multilocularis | thymidylate synthase | 0.0244 | 0.3799 | 1 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0125 | 0.0664 | 0.0664 |
Brugia malayi | Cation transporter family protein | 0.0125 | 0.0664 | 0.1184 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0125 | 0.0664 | 0.1747 |
Brugia malayi | hypothetical protein | 0.0116 | 0.0436 | 0.0778 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0125 | 0.0664 | 0.0664 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0125 | 0.0664 | 0.1747 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0664 | 0.0664 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0125 | 0.0664 | 0.1184 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0125 | 0.0664 | 0.1747 |
Loa Loa (eye worm) | ACC-1 protein | 0.0125 | 0.0664 | 0.0664 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0125 | 0.0664 | 0.0664 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0125 | 0.0664 | 0.1747 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0125 | 0.0664 | 0.1184 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0244 | 0.3799 | 1 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0125 | 0.0664 | 0.1747 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0125 | 0.0664 | 0.1747 |
Schistosoma mansoni | nAChR subunit | 0.0125 | 0.0664 | 0.1747 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0125 | 0.0664 | 0.1747 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0313 | 0.5607 | 1 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0125 | 0.0664 | 0.1747 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0125 | 0.0664 | 0.1184 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0664 | 0.0664 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0125 | 0.0664 | 0.1184 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0664 | 0.0664 |
Brugia malayi | thymidylate synthase | 0.0244 | 0.3799 | 0.6776 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0344 | 0.6415 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0664 | 0.0664 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0664 | 0.0664 |
Brugia malayi | Cation transporter family protein | 0.0125 | 0.0664 | 0.1184 |
Schistosoma mansoni | nAChR subunit | 0.0125 | 0.0664 | 0.1747 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0125 | 0.0664 | 0.1747 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0664 | 0.0664 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.4094 | 0.4094 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0125 | 0.0664 | 0.1747 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0125 | 0.0664 | 0.1747 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0125 | 0.0664 | 0.1747 |
Echinococcus granulosus | thymidylate synthase | 0.0244 | 0.3799 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.