Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ROS proto-oncogene 1, receptor tyrosine kinase | Starlite/ChEMBL | No references |
Homo sapiens | ret proto-oncogene | Starlite/ChEMBL | No references |
Homo sapiens | neurotrophic tyrosine kinase, receptor, type 1 | No references | |
Homo sapiens | activin A receptor type II-like 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | tyrosine protein kinase | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Echinococcus multilocularis | serine:threonine protein kinase receptor R3 | Get druggable targets OG5_157629 | All targets in OG5_157629 |
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Loa Loa (eye worm) | TK protein kinase | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Echinococcus granulosus | tyrosine protein kinase | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | protein kinase | 0.0115 | 0.2337 | 0.9415 |
Entamoeba histolytica | protein kinase, putative | 0.0007 | 0 | 0.5 |
Echinococcus multilocularis | activin receptor type | 0.0121 | 0.2475 | 0.2382 |
Loa Loa (eye worm) | hypothetical protein | 0.0288 | 0.6066 | 0.9631 |
Entamoeba histolytica | hypothetical protein | 0.0007 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase | 0.0294 | 0.6204 | 0.6157 |
Brugia malayi | Protein kinase domain containing protein | 0.0294 | 0.6204 | 1 |
Echinococcus multilocularis | TGF beta receptor type 1 | 0.0115 | 0.2337 | 0.2243 |
Echinococcus granulosus | activin receptor type | 0.0121 | 0.2475 | 0.3869 |
Echinococcus granulosus | tyrosine protein kinase | 0.0294 | 0.6204 | 1 |
Loa Loa (eye worm) | TK protein kinase | 0.0294 | 0.6204 | 1 |
Schistosoma mansoni | protein kinase | 0.0121 | 0.2475 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0007 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0007 | 0 | 0.5 |
Echinococcus granulosus | TGF beta receptor type 1 | 0.0115 | 0.2337 | 0.3643 |
Echinococcus granulosus | TGF-beta receptor type-1 | 0.0115 | 0.2337 | 0.3643 |
Entamoeba histolytica | leucine-rich repeat domain-containing protein | 0.0007 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.992 nM | In Vitro Kinase Activity Assay | BINDINGDB. | No reference |
IC50 (binding) | = 11.15 nM | In Vitro Kinase Activity Assay | BINDINGDB. | No reference |
IC50 (binding) | = 14.59 nM | In Vitro Kinase Activity Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.