Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | monoamine oxidase A | Starlite/ChEMBL | No references |
Homo sapiens | monoamine oxidase B | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | amine oxidase, flavin-containing family protein | monoamine oxidase B | 520 aa | 462 aa | 19.7 % |
Brugia malayi | amine oxidase, flavin-containing family protein | monoamine oxidase A | 527 aa | 474 aa | 22.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0095 | 0 | 0.5 |
Echinococcus granulosus | aminopeptidase N | 0.0323 | 0.3669 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.029 | 0.3131 | 1 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0095 | 0 | 0.5 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0095 | 0 | 0.5 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0095 | 0 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0095 | 0 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0717 | 1 | 1 |
Onchocerca volvulus | 0.0323 | 0.3669 | 1 | |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0095 | 0 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0095 | 0 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0262 | 0.2677 | 0.8549 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0667 | 0.9188 | 0.5 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0095 | 0 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.0323 | 0.3669 | 1 |
Brugia malayi | Peptidase family M1 containing protein | 0.0323 | 0.3669 | 1 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0095 | 0 | 0.5 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0095 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0095 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.2139 | 0.683 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0095 | 0 | 0.5 |
Entamoeba histolytica | aminopeptidase, putative | 0.0095 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 10000 nM | BindingDB_Patents: Activity Assay. Inhibitory activity of compounds was evaluated by a homogeneous luminescent method, the MAO-Glo Assay (Promega), measuring the monoamine oxidase activity (MAOs) from recombinant source (microsomes from baculovirus infected insect cells, Sigma). Experiments were performed according to the Supplier's procedure, incubating human recombinant MAO-A or MAO-B with a luminogenic substrate, a derivative of beetle luciferin ((4S)-4,5-dihydro-2-(6-hydroxybenzothiazolyl)-4-thiazolecarboxylic acid). MAOs converts this luciferin derivative to methyl ester luciferin and only compounds that interfere with the ability of the enzyme to use the pro-luminescent substrate will cause changes in the resulting luminescent signal. | ChEMBL. | No reference |
IC50 (binding) | = 10000 nM | Activity Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.