Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | androgen receptor | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0009 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0009 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0009 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0009 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0009 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0009 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0009 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0009 | 0.5 | 0.5 | |
Schistosoma mansoni | nuclear hormone receptor | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0009 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0009 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 20 nM | BindingDB_Patents: Biological Assay. In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compounds of this invention are shown to demonstrate significant affinity for the androgen receptor. The assay was performed as specified by the manufacturer (Invitrogen, Madison, Wis.). Briefly, 1 ul of 10 mM compound was added to 500 ul of AR screening buffer in a 1.5 ml eppendorf tube to make a 2x10-5M stock. 10-fold serial dilutions of the test compounds were prepared ranging in concentration from 10-5M to 10-12M. Each dilution was added in triplicate to a black 384-microtiter plate. The test compounds will be diluted 2-fold in the final reaction. 2xAR-Fluormone complex was prepared with 2 nM Flourmone AL Green and 30 nM AR. 25 ul of 2x complex was aliquoted to each reaction well, such that the final reaction volume was 50 ul per well. The plate was sealed with a foil cover and incubated in the dark at room temperature. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.