Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cathepsin C | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium vivax | dipeptidyl aminopeptidase 3, putative | cathepsin C | 141 aa | 152 aa | 22.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | dipeptidyl aminopeptidase 1, putative | 0.023 | 0.1408 | 1 |
Toxoplasma gondii | preprocathepsin c precursor, putative | 0.023 | 0.1408 | 1 |
Plasmodium vivax | dipeptidyl aminopeptidase 2, putative | 0.023 | 0.1408 | 1 |
Schistosoma mansoni | dipeptidyl-peptidase I (C01 family) | 0.023 | 0.1408 | 0.1656 |
Schistosoma mansoni | hypothetical protein | 0.0793 | 0.8507 | 1 |
Toxoplasma gondii | cathepsin CPC1 | 0.023 | 0.1408 | 1 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0118 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0143 | 0.0308 | 0.5 |
Echinococcus multilocularis | kinesin family 1 | 0.0912 | 1 | 0.5 |
Brugia malayi | Kinesin motor domain containing protein | 0.0118 | 0 | 0.5 |
Plasmodium falciparum | dipeptidyl aminopeptidase 2 | 0.023 | 0.1408 | 1 |
Entamoeba histolytica | kinesin, putative | 0.0118 | 0 | 0.5 |
Plasmodium falciparum | dipeptidyl aminopeptidase 1 | 0.023 | 0.1408 | 1 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.023 | 0.1408 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 123 nM | BindingDB_Patents: Inhibition Assay. The following buffers were used: MES buffer: 25 mM MES, 50 mM NaCl, 5 mM DTT, adjusted to pH 6.0, containing 0.1% BSA; TAGZyme Buffer: 20 mM NaH2PO4, 150 mM NaCl adjusted to pH 6.0 with HCl. Assay Conditions: The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 ug/ml, respectively), and then activated by mixing in a 1:2 ratio with a Cysteamine aqueous solution (2 mM) and incubating for 5 min at room temperature.Five uL test compound (final concentration 0.1 nM to 100 uM) in aqua bidest (containing 4% DMSO, final DMSO concentration 1%) were mixed with 10 uL of DPPI in MES buffer (final concentration 0.0125 ng/uL) and incubated for 10 min. Then, 5 uL of substrate in MES buffer (final concentration 50 uM) were added. The microtiter plates were then incubated at room temperature for 30 min. Then, the reaction was stopped by adding 10 uL of Gly-Phe-DMK in MES-buffer (final concentration 1 uM). | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.