Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Fibulin-1 precursor | 0.0016 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 1 | 1 |
Onchocerca volvulus | Arrow homolog | 0.0016 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 1 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0016 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 1 | 1 |
Echinococcus multilocularis | laminin | 0.0016 | 1 | 1 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0016 | 1 | 1 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0016 | 1 | 1 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0016 | 1 | 1 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0016 | 1 | 1 |
Echinococcus multilocularis | fibrillin 1 | 0.0016 | 1 | 1 |
Echinococcus granulosus | Tolloid protein 1 | 0.0016 | 1 | 1 |
Echinococcus granulosus | laminin | 0.0016 | 1 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0016 | 1 | 0.5 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0016 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 1 | 1 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0016 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 1 | 1 |
Schistosoma mansoni | egf-like domain protein | 0.0016 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
aPTT (functional) | 0 s | Activated partial thromboplastin time was determined after (iv) bolus dose of 0.75 mg/kg followed by an infusion of 50 microg/kg/min in rat arterial thrombosis model; Not determined | ChEMBL. | 11934583 |
Ki (binding) | = 75 nM | Inhibition of amidolytic activity of thrombin | ChEMBL. | 11934583 |
Ki (binding) | = 75 nM | Inhibition of amidolytic activity of thrombin | ChEMBL. | 11934583 |
MOT (functional) | 0 min | Mean occlusion time after (iv) bolus dose of 0.75 mg/kg followed by an infusion of 50 microg/kg/min was determined in rat arterial thrombosis model; Not determined | ChEMBL. | 11934583 |
Ratio (binding) | = 37 | Selectivity ratio, ratio of Ki against trypsin to Ki against thrombin | ChEMBL. | 11934583 |
TT (functional) | 0 s | Thrombin time was determined after (iv) bolus dose of 0.75 mg/kg followed by an infusion of 50 microg/kg/min in rat arterial thrombosis model; Not determined | ChEMBL. | 11934583 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.