Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphorylase, glycogen | Starlite/ChEMBL | References |
Homo sapiens | phosphorylase, glycogen, liver | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Glycogen phosphorylase | 0.0261 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.199 | 0.199 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0113 | 0.1883 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0133 | 0.0133 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0261 | 1 | 1 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0261 | 1 | 1 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0261 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0261 | 1 | 1 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0113 | 0.1883 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0115 | 0.199 | 0.199 |
Schistosoma mansoni | glycogen phosphorylase | 0.0113 | 0.1883 | 0.1883 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0115 | 0.199 | 0.199 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0081 | 0.0133 | 0.0133 |
Schistosoma mansoni | glycogen phosphorylase | 0.0261 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0261 | 1 | 1 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0261 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0261 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0115 | 0.199 | 0.199 |
Echinococcus granulosus | glycogen phosphorylase | 0.0261 | 1 | 1 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0081 | 0.0133 | 0.0133 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0261 | 1 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0261 | 1 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.0261 | 1 | 1 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0261 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0261 | 1 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0261 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 7.13 uM | In vitro inhibition of glucagon-stimulated glycogenolysis in primary rat hepatocytes | ChEMBL. | 14505637 |
IC50 (binding) | = 104 nM | In vitro inhibitory activity against human liver glycogen phosphorylase a (HLGPa) | ChEMBL. | 14505637 |
IC50 (binding) | = 104 nM | In vitro inhibitory activity against human liver glycogen phosphorylase a (HLGPa) | ChEMBL. | 14505637 |
IC50 (binding) | = 185 nM | In vitro inhibitory activity against human muscle glycogen phosphorylase a (HMGPa) | ChEMBL. | 14505637 |
IC50 (binding) | = 185 nM | In vitro inhibitory activity against human muscle glycogen phosphorylase a (HMGPa) | ChEMBL. | 14505637 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.