Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0025 | 0.0408 | 0.0408 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5428 | 0.5658 |
Toxoplasma gondii | kringle domain-containing protein | 0.0079 | 0.5428 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0079 | 0.5428 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.083 | 0.0865 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.9592 | 1 |
Brugia malayi | Kringle domain containing protein | 0.0079 | 0.5428 | 0.5658 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0079 | 0.5428 | 0.5658 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0123 | 0.9592 | 0.9592 |
Mycobacterium ulcerans | hypothetical protein | 0.0021 | 0 | 0.5 |
Onchocerca volvulus | 0.0123 | 0.9592 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.9592 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0079 | 0.5428 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.5428 | 0.5428 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0079 | 0.5428 | 1 |
Brugia malayi | Trypsin family protein | 0.0123 | 0.9592 | 1 |
Onchocerca volvulus | 0.0102 | 0.7637 | 0.7962 | |
Onchocerca volvulus | 0.0079 | 0.5428 | 0.5658 | |
Leishmania major | hypothetical protein, conserved | 0.0079 | 0.5428 | 0.5 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0079 | 0.5428 | 1 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0079 | 0.5428 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0079 | 0.5428 | 0.5658 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
HDL-C change (functional) | < 49 % | Average percentage HDLC change in 6 cholesterol cholic acid-fed male rats (versus control) after treatment for 8 days at a dose of 100 mg/kg/day | ChEMBL. | 11212105 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.