Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0273 | 1 | 0.5 | |
Echinococcus granulosus | enteropeptidase | 0.0273 | 1 | 0.5 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0273 | 1 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0273 | 1 | 1 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0273 | 1 | 0.5 |
Echinococcus multilocularis | enteropeptidase | 0.0273 | 1 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0273 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0273 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0273 | 1 | 1 |
Brugia malayi | Trypsin family protein | 0.0273 | 1 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0273 | 1 | 1 |
Loa Loa (eye worm) | trypsin family protein | 0.0273 | 1 | 0.5 |
Onchocerca volvulus | 0.0273 | 1 | 0.5 | |
Onchocerca volvulus | 0.0273 | 1 | 0.5 | |
Echinococcus multilocularis | Mastin | 0.0273 | 1 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0273 | 1 | 1 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0273 | 1 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0273 | 1 | 0.5 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0273 | 1 | 0.5 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0273 | 1 | 0.5 |
Onchocerca volvulus | 0.0273 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 1 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0273 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0273 | 1 | 1 |
Onchocerca volvulus | 0.0273 | 1 | 0.5 | |
Trypanosoma brucei | RNA helicase, putative | 0.01 | 0 | 0.5 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0273 | 1 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0273 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0273 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 1 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0273 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0273 | 1 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0273 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 1 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0273 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0273 | 1 | 0.5 |
Echinococcus granulosus | Mastin | 0.0273 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 1 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0273 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0273 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0273 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0273 | 1 | 1 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0273 | 1 | 0.5 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0273 | 1 | 0.5 |
Onchocerca volvulus | 0.0273 | 1 | 0.5 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0273 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 1 | 0.5 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0273 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 1 | 0.5 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0273 | 1 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0273 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 1 | 1 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0273 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 84 uM | Cytostatic concentration of the compound required to reduce MT-4 cell viability in mock-infected cell cultures | ChEMBL. | 15189038 |
CC50 (functional) | = 138 uM | Cytostatic concentration of the compound required to inhibit proliferation of CEM cells | ChEMBL. | 15189038 |
EC50 (functional) | = 1.26 uM | Effective concentration of the compound required to inhibit HIV-1 induced cytopathicity in human MT-4 cell lines | ChEMBL. | 15189038 |
EC50 (functional) | = 3 uM | Effective concentration of the compound required to inhibit HIV-1 induced cytopathicity in human CEM cell lines | ChEMBL. | 15189038 |
EC50 (functional) | = 20 uM | Effective concentration of the compound required to inhibit HIV-1E138K induced cytopathicity in human MT-4 cell lines | ChEMBL. | 15189038 |
EC50 (functional) | > 50 uM | Effective concentration of the compound required to inhibit HIV-2 induced cytopathicity in human MT-4 cell lines | ChEMBL. | 15189038 |
EC50 (functional) | > 50 uM | Effective concentration of the compound required to inhibit HIV-2 induced cytopathicity in human CEM cell lines | ChEMBL. | 15189038 |
IC50 (binding) | = 3.8 uM | Inhibitory concentration against wild type HIV-1 reverse transcriptase (RT) using poly rC.dG as the template or primer | ChEMBL. | 15189038 |
IC50 (binding) | = 312 uM | Inhibitory concentration against wild type HIV-1/138Lys reverse transcriptase (RT) using [3H]-dGTP as a radioligand | ChEMBL. | 15189038 |
logP (ADMET) | = 5.02 | Partition coefficient (logP) | ChEMBL. | 15189038 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.