Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0053 | 0.0728 | 0.0824 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.0261 | 1 | 1 |
Echinococcus granulosus | Mastin | 0.0053 | 0.0728 | 0.0824 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0261 | 1 | 1 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.0235 | 0.8839 | 1 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0053 | 0.0728 | 0.0824 |
Onchocerca volvulus | 0.0053 | 0.0728 | 1 | |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0053 | 0.0728 | 0.0824 |
Echinococcus granulosus | enteropeptidase | 0.0053 | 0.0728 | 0.0824 |
Mycobacterium ulcerans | hypothetical protein | 0.0053 | 0.0728 | 0.5 |
Onchocerca volvulus | 0.0053 | 0.0728 | 1 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Echinococcus multilocularis | Mastin | 0.0053 | 0.0728 | 0.0824 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0728 | 0.0728 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0728 | 0.0728 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Echinococcus multilocularis | enteropeptidase | 0.0053 | 0.0728 | 0.0824 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0053 | 0.0728 | 0.0728 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Onchocerca volvulus | 0.0053 | 0.0728 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0728 | 0.0728 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.0235 | 0.8839 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0728 | 0.0728 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.0235 | 0.8839 | 0.8839 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.0235 | 0.8839 | 0.8839 |
Brugia malayi | Trypsin family protein | 0.0053 | 0.0728 | 0.0728 |
Brugia malayi | Trypsin family protein | 0.0053 | 0.0728 | 0.0728 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Onchocerca volvulus | 0.0053 | 0.0728 | 1 | |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0053 | 0.0728 | 0.0824 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0053 | 0.0728 | 0.0728 |
Onchocerca volvulus | 0.0053 | 0.0728 | 1 | |
Brugia malayi | Trypsin family protein | 0.0053 | 0.0728 | 0.0728 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0053 | 0.0728 | 0.0824 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0728 | 0.0728 |
Brugia malayi | Trypsin family protein | 0.0053 | 0.0728 | 0.0728 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0728 | 0.0728 |
Loa Loa (eye worm) | trypsin family protein | 0.0053 | 0.0728 | 0.0728 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0053 | 0.0728 | 0.0728 |
Onchocerca volvulus | 0.0053 | 0.0728 | 1 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Brugia malayi | hypothetical protein | 0.0053 | 0.0728 | 0.0728 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0053 | 0.0728 | 0.0824 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.0235 | 0.8839 | 0.8839 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0053 | 0.0728 | 0.0824 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0728 | 0.0728 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0053 | 0.0728 | 0.0824 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0728 | 0.0728 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0728 | 0.0728 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 18 % | Tested in vitro for inhibition of [3H]-spiperone binding to dopamine receptor D2 at the dose of 10 e-5 M | ChEMBL. | 7901417 |
Inhibition (binding) | = 18 % | Tested in vitro for inhibition of [3H]-spiperone binding to dopamine receptor D2 at the dose of 10 e-5 M | ChEMBL. | 7901417 |
Inhibition (binding) | = 37 % | Tested in vitro for inhibition of [3H]-spiperone binding to dopamine receptor D2 at the dose of 10 e-5 M | ChEMBL. | 7901417 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.