Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0393 | 0.0635 | 0.0632 |
Trypanosoma cruzi | serine carboxypeptidase S28, putative | 0.0086 | 0.006 | 0.0054 |
Trypanosoma cruzi | serine carboxypeptidase S28, putative | 0.0086 | 0.006 | 0.0054 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0086 | 0.006 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0608 | 0.1036 | 1 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0086 | 0.006 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0086 | 0.006 | 0.5 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0334 | 0.0524 | 0.0335 |
Toxoplasma gondii | serine carboxypeptidase s28 protein | 0.0086 | 0.006 | 1 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0086 | 0.006 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0086 | 0.006 | 0.5 |
Trichomonas vaginalis | prolylcarboxypeptidase, putative | 0.0086 | 0.006 | 0.5 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0086 | 0.006 | 0.0952 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0565 | 0.0956 | 1 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0086 | 0.006 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0393 | 0.0635 | 0.0632 |
Trichomonas vaginalis | prolylcarboxypeptidase, putative | 0.0086 | 0.006 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0393 | 0.0635 | 0.0632 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0086 | 0.006 | 0.5 |
Onchocerca volvulus | 0.0086 | 0.006 | 0.5 | |
Brugia malayi | NNMT/PNMT/TEMT family protein | 0.2247 | 0.4101 | 0.4099 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0086 | 0.006 | 0.5 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0393 | 0.0635 | 1 |
Brugia malayi | Serine protease Z688.6 precursor | 0.0086 | 0.006 | 0.0057 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0086 | 0.006 | 0.5 |
Brugia malayi | Serine carboxypeptidase S28 family protein | 0.0393 | 0.0635 | 0.0632 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.2247 | 0.4101 | 0.4099 |
Schistosoma mansoni | lysosomal Pro-Xaa carboxypeptidase (S28 family) | 0.0393 | 0.0635 | 1 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0086 | 0.006 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.5402 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0086 | 0.006 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2247 | 0.4101 | 0.4099 |
Loa Loa (eye worm) | hypothetical protein | 0.5402 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2247 | 0.4101 | 0.4099 |
Trichomonas vaginalis | lysosomal pro-X carboxypeptidase, putative | 0.0086 | 0.006 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0086 | 0.006 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0158 | 0.0195 | 0.0189 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.0086 | 0.006 | 0.0952 |
Leishmania major | C-8 sterol isomerase-like protein | 0.5402 | 1 | 1 |
Brugia malayi | Serine protease Z688.6 precursor | 0.0086 | 0.006 | 0.0057 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0334 | 0.0524 | 0.0518 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0334 | 0.0524 | 0.0335 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0086 | 0.006 | 0.5 |
Trypanosoma cruzi | putative prolyl carboxypeptidase, putative | 0.0086 | 0.006 | 0.0054 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.5402 | 1 | 1 |
Entamoeba histolytica | serine carboxypeptidase (S28) family protein | 0.0086 | 0.006 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.006 | 0.0057 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0608 | 0.1036 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0334 | 0.0524 | 0.0518 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0086 | 0.006 | 0.5 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.0393 | 0.0635 | 1 |
Entamoeba histolytica | serine carboxypeptidase (S28) family protein | 0.0086 | 0.006 | 0.5 |
Giardia lamblia | Thymus-specific serine protease precursor | 0.0086 | 0.006 | 0.5 |
Entamoeba histolytica | serine carboxypeptidase (S28) family protein | 0.0086 | 0.006 | 0.5 |
Giardia lamblia | Serine peptidase, putative | 0.0086 | 0.006 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2761 | 0.5062 | 0.5061 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 25 uM | Inhibition of trypanothione reductase from T. cruzi, in the presence 57 microM of trypanothione T(SH)2 | ChEMBL. | 9871730 |
IC50 (binding) | = 25 uM | Inhibition of trypanothione reductase from T. cruzi, in the presence 57 microM of trypanothione T(SH)2 | ChEMBL. | 9871730 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.