Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nmda type glutamate receptor | 0.0104 | 0.8094 | 1 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0024 | 0.0419 | 0.5 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0024 | 0.0419 | 0.0518 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0029 | 0.0861 | 0.1063 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0029 | 0.0861 | 0.1063 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0104 | 0.8094 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0029 | 0.0861 | 0.1063 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0024 | 0.0419 | 0.5 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0024 | 0.0419 | 0.0518 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0024 | 0.0419 | 0.5 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0024 | 0.0419 | 0.0518 |
Echinococcus granulosus | glutamate receptor 2 | 0.0029 | 0.0861 | 0.1063 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0029 | 0.0861 | 0.1063 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0095 | 0.7233 | 0.8937 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0029 | 0.0861 | 0.1063 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0024 | 0.0419 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0029 | 0.0861 | 0.1063 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0095 | 0.7233 | 0.8937 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0029 | 0.0861 | 0.1063 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0029 | 0.0861 | 0.1063 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0029 | 0.0861 | 0.1063 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.01 | 0.7674 | 0.9482 |
Echinococcus granulosus | nmda type glutamate receptor | 0.01 | 0.7674 | 0.9482 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.12 uM | Concentration required for 50% Inhibition of responses at cloned NR1A/2AB NMDA expressed in Xenopus oocytes | ChEMBL. | 10978188 |
IC50 (binding) | = 0.12 uM | Concentration required for 50% Inhibition of responses at cloned NR1A/2AB NMDA expressed in Xenopus oocytes | ChEMBL. | 10978188 |
IC50 (binding) | = 39 uM | Concentration required for 50% Inhibition of responses at cloned NR1A/2A NMDA expressed in Xenopus oocytes | ChEMBL. | 10978188 |
IC50 (binding) | = 39 uM | Concentration required for 50% Inhibition of responses at cloned NR1A/2A NMDA expressed in Xenopus oocytes | ChEMBL. | 10978188 |
IC50 (binding) | > 100 uM | Concentration required for 50% Inhibition of responses at cloned NR1A/2C NMDA expressed in Xenopus oocytes | ChEMBL. | 10978188 |
IC50 (binding) | > 100 uM | Concentration required for 50% Inhibition of responses at cloned NR1A/2C NMDA expressed in Xenopus oocytes | ChEMBL. | 10978188 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.