Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | estrogen receptor 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0007 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0007 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0007 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0007 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0007 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0007 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0007 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0007 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0007 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0007 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0007 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0007 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0007 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0007 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0007 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0007 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0007 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0007 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0007 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0007 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0007 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0007 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0007 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0007 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0007 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0007 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0007 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0007 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0007 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0007 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0007 | 0.5 | 0.5 | |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0007 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0007 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0007 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0007 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0007 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0007 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0007 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0007 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0007 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0007 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0007 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0007 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0007 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0007 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0007 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0007 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0007 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0007 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0007 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0007 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0007 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0007 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0007 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0007 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0007 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0007 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0007 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0007 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0007 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0007 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0007 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 150 nM | BindingDB_Patents: Binding Assay. The competition assay was performed in a 96-well plate (polystyrene*) which binds <2.0% of the total input [3H]-17beta-estradiol and each data point was gathered in triplicate. 100 uG/100 uL of the receptor preparation was aliquoted per well. A saturating dose of 2.5 nM [3H]17beta-estradiol+competitor (or buffer) in a 50 uL volume was added in the preliminary competition when 100x and 500x competitor were evaluated, only 0.8 nM [3H]17beta-estradiol was used. The plate was incubated at room temperature for 2.5 h. At the end of this incubation period 150 uL of ice-cold dextran coated charcoal (5% activated charcoal coated with 0.05% 69K dextran) was added to each well and the plate was immediately centrifuged at 99 g for 5 minutes at 4 C. 200 uL of the supernatant solution was then removed for scintillation counting. Samples were counted to 2% or 10 minutes, whichever occurs first. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.