Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | transient receptor potential cation channel | 0.0017 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.5 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0017 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.5 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0017 | 0.5 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0017 | 0.5 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0017 | 0.5 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0017 | 0.5 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0017 | 0.5 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0017 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Induction of melanogenesis in C57BL/6 depigmentation mouse assessed as increase in melanin content of hair follicle on depigmented skin at 1.6 to 4.8 mg/kg, ip for 2 weeks by H&E stainig-based histomorphology | ChEMBL. | 25748162 | |
Activity (functional) | Induction of melanogenesis in C57BL/6 depigmentation mouse assessed as increase in MITF protein expression at 1.6 to 4.8 mg/kg, ip for 2 weeks measured on day 12 by H&E staining-based histomorphology | ChEMBL. | 25748162 | |
Activity (functional) | Induction of melanogenesis in C57BL/6 depigmentation mouse assessed as increase in TRP-2 protein expression at 1.6 to 4.8 mg/kg, ip for 2 weeks measured on day 12 by H&E staining-based histomorphology | ChEMBL. | 25748162 | |
Activity (functional) | Induction of melanogenesis in C57BL/6 depigmentation mouse assessed as increase in TRP-1 protein expression at 1.6 to 4.8 mg/kg, ip for 2 weeks measured on day 12 by H&E staining-based histomorphology | ChEMBL. | 25748162 | |
Activity (functional) | Induction of melanogenesis in C57BL/6 depigmentation mouse assessed as increase in tyrosinase protein expression at 1.6 to 4.8 mg/kg, ip for 2 weeks measured on day 12 by H&E staining-based histomorphology | ChEMBL. | 25748162 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.