Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.0158 | 0.1729 | 0.1664 |
Echinococcus granulosus | epidermal growth factor receptor | 0.016 | 0.1773 | 0.1708 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0475 | 1 | 1 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0475 | 1 | 0.5 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0298 | 0.5374 | 0.5337 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0475 | 1 | 0.5 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.016 | 0.1773 | 0.1708 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0298 | 0.5374 | 0.5374 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0475 | 1 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0475 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0475 | 1 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0298 | 0.5374 | 0.5337 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.016 | 0.1773 | 0.1773 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0475 | 1 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0475 | 1 | 1 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0298 | 0.5374 | 0.5337 |
Schistosoma mansoni | tyrosine kinase | 0.0158 | 0.1729 | 0.1664 |
Schistosoma mansoni | tyrosine kinase | 0.0298 | 0.5374 | 0.5337 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0475 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0475 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.016 | 0.1773 | 0.1708 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0475 | 1 | 0.5 |
Echinococcus multilocularis | insulin receptor | 0.0095 | 0.0078 | 0.0078 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0475 | 1 | 1 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0475 | 1 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0475 | 1 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0095 | 0.0078 | 0.0078 |
Schistosoma mansoni | tyrosine kinase | 0.0158 | 0.1729 | 0.1664 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0475 | 1 | 0.5 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0475 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.016 | 0.1773 | 0.1708 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0475 | 1 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0475 | 1 | 0.5 |
Plasmodium vivax | RNA helicase-1, putative | 0.0475 | 1 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0475 | 1 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0475 | 1 | 1 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0475 | 1 | 0.5 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0475 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 6.59 nM | Compound was tested in vitro for cytotoxicity against L1210 murine cell line (48 h exposure to compound) | ChEMBL. | 10479282 |
IC50 (functional) | = 6.59 nM | Compound was tested in vitro for cytotoxicity against L1210 murine cell line (48 h exposure to compound) | ChEMBL. | 10479282 |
IC50 (functional) | = 8.38 nM | Compound was tested in vitro for cytotoxicity against HL60 human leukemia cell line (72 h exposure to compound) | ChEMBL. | 10479282 |
IC50 (functional) | = 8.38 nM | Compound was tested in vitro for cytotoxicity against HL60 human leukemia cell line (72 h exposure to compound) | ChEMBL. | 10479282 |
IC50 (functional) | = 23.52 nM | Compound was tested in vitro for cytotoxicity against MDR cell line K562R (72 h exposure to compound) | ChEMBL. | 10479282 |
IC50 (functional) | = 23.52 nM | Compound was tested in vitro for cytotoxicity against MDR cell line K562R (72 h exposure to compound) | ChEMBL. | 10479282 |
IC50 (functional) | = 53.41 nM | Compound was tested in vitro for cytotoxicity against MDR cell line K562R (RI) (72 h exposure to compound) | ChEMBL. | 10479282 |
IC50 (functional) | = 53.41 nM | Compound was tested in vitro for cytotoxicity against MDR cell line K562R (RI) (72 h exposure to compound) | ChEMBL. | 10479282 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 10479282 | |
Homo sapiens | ChEMBL23 | 10479282 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.