Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0011 | 0 | 0.5 |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.0237 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0011 | 0 | 0.5 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0092 | 0.3602 | 0.5 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.0237 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0237 | 1 | 1 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.0237 | 1 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0092 | 0.3602 | 0.5 |
Trypanosoma brucei | Aph-1 protein, putative | 0.0092 | 0.3602 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (functional) | > 0.0001 M | Compound was tested for its inhibitory activity against L1210 lymphoid leukemia cells at 10 ug/mL | ChEMBL. | 3806615 |
T/C (functional) | < 125 % | Compound was tested for mean survival time of treated mice in days / mean survival time of control mice x 100 against L1210 lymphoid leukemia cells | ChEMBL. | 3806615 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.