Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | phosphoribosylglycinamide formyltransferase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | selenide water dikinase | 0.0013 | 0.0081 | 0.0199 |
Brugia malayi | selenium donor protein | 0.0013 | 0.0081 | 0.0199 |
Mycobacterium tuberculosis | Probable phosphoribosylamine--glycine ligase PurD (GARS) (glycinamide ribonucleotide synthetase) (phosphoribosylglycinamide synt | 0.0026 | 0.0845 | 0.4879 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.018 | 1 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.1442 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0381 | 0.0931 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.1442 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0032 | 0.1215 | 0.7244 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.0381 | 0.22 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0081 | 0.4087 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0036 | 0.1442 | 0.1371 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.1442 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0381 | 0.2641 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.1442 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.0381 | 0.1912 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0081 | 0.4087 | 1 |
Onchocerca volvulus | 0.0032 | 0.1165 | 0.2851 | |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.0381 | 0.0302 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0381 | 0.0931 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0081 | 0.4087 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.1442 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0032 | 0.1215 | 0.1143 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 0.1442 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0381 | 0.0302 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylaminoimidazole synthetase | 0.004 | 0.1646 | 0.1578 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0081 | 0.4087 | 1 |
Mycobacterium tuberculosis | Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) | 0.004 | 0.1646 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0381 | 0.5 |
Schistosoma mansoni | selinide water dikinase | 0.0013 | 0.0081 | 0.0565 |
Mycobacterium ulcerans | phosphoribosylaminoimidazole synthetase | 0.004 | 0.1646 | 0.1578 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.0381 | 0.22 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.1442 | 1 |
Echinococcus multilocularis | 0.0013 | 0.0081 | 0.0199 | |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.018 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.4087 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0381 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0081 | 0.4087 | 1 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0081 | 0.4087 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.1442 | 0.1371 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0081 | 0.4087 | 1 |
Loa Loa (eye worm) | selenium donor protein | 0.0013 | 0.0081 | 0.0199 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.1442 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0381 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0381 | 0.0931 |
Onchocerca volvulus | 0.004 | 0.1646 | 0.4028 | |
Brugia malayi | Inositol-1 | 0.0036 | 0.1442 | 0.3527 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.0381 | 0.5 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0081 | 0.4087 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.1442 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.1442 | 0.3527 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE PURM (AIRS) (PHOSPHORIBOSYL-AMINOIMIDAZOLE SYNTHETASE) (AIR SYNTHASE) | 0.004 | 0.1646 | 0.1578 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0381 | 0.2641 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0381 | 0.22 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.1442 | 1 |
Onchocerca volvulus | Putative nachr subunit | 0.0081 | 0.4087 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.1442 | 0.3527 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0381 | 0.0931 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.1442 | 0.3527 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0381 | 0.22 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.1442 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.0381 | 0.22 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.008 ug ml-1 | The compound was tested for its cytotoxicity against CCRF-CEM human leukemic cells using 72 hrs assay | ChEMBL. | No reference |
IC50 (functional) | = 0.008 ug ml-1 | The compound was tested for its cytotoxicity against CCRF-CEM human leukemic cells using 72 hrs assay | ChEMBL. | No reference |
Ki (binding) | = 0.000000019 uM | Inhibitory activity against glycinamide ribonucleotide formyltransferase (GARFT) from L1210 murine leukemic cells | ChEMBL. | No reference |
Ki (binding) | = 0.000000019 uM | Inhibitory activity against glycinamide ribonucleotide formyltransferase (GARFT) from L1210 murine leukemic cells | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.