Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | FAD binding domain containing protein | 0.0097 | 0.3797 | 0.6584 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0097 | 0.3797 | 0.3206 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0097 | 0.3797 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0097 | 0.3797 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.006 | 0.087 | 0.0183 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.006 | 0.087 | 0.0183 |
Onchocerca volvulus | Matrilysin homolog | 0.0107 | 0.4597 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0176 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0097 | 0.3797 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0086 | 0.2927 | 0.5 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0059 | 0.0786 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0097 | 0.3797 | 0.3206 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0097 | 0.3797 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0097 | 0.3797 | 0.3206 |
Giardia lamblia | Hypothetical protein | 0.0086 | 0.2927 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0097 | 0.3797 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0097 | 0.3797 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0097 | 0.3797 | 1 |
Brugia malayi | Hemopexin family protein | 0.0068 | 0.1548 | 0.1666 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0097 | 0.3797 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0097 | 0.3797 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0097 | 0.3797 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0097 | 0.3797 | 0.6584 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.006 | 0.087 | 0.2291 |
Loa Loa (eye worm) | matrixin family protein | 0.0107 | 0.4597 | 0.8334 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0097 | 0.3797 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0097 | 0.3797 | 0.3206 |
Loa Loa (eye worm) | matrixin family protein | 0.0117 | 0.5359 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0097 | 0.3797 | 1 |
Brugia malayi | Matrixin family protein | 0.0117 | 0.5359 | 1 |
Leishmania major | p450 reductase, putative | 0.0097 | 0.3797 | 1 |
Brugia malayi | flavodoxin family protein | 0.0097 | 0.3797 | 0.6584 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0097 | 0.3797 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.1548 | 0.4077 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0107 | 0.4597 | 1 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0059 | 0.0786 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0097 | 0.3797 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3797 | 0.6584 |
Chlamydia trachomatis | sulfite reductase | 0.006 | 0.087 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 35.9 uM | Inhibition of ADP-induced aggregation of human blood platelets in plasma | ChEMBL. | 1404231 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.