Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | lipoxygenase | 0.0085 | 0.008 | 0.0092 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0106 | 0.0117 | 0.0062 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0122 | 0.0147 | 0.0092 |
Schistosoma mansoni | kinesin eg-5 | 0.0715 | 0.1232 | 0.1418 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0098 | 0.0102 | 0.0118 |
Entamoeba histolytica | kinesin, putative | 0.0715 | 0.1232 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0072 | 0.0055 | 0.0063 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0715 | 0.1232 | 1 |
Echinococcus multilocularis | kinesin family 1 | 0.5505 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0122 | 0.0147 | 0.0169 |
Plasmodium falciparum | kinesin-5 | 0.0715 | 0.1232 | 0.5 |
Giardia lamblia | Kinesin-5 | 0.0715 | 0.1232 | 0.5 |
Plasmodium vivax | kinesin-5 | 0.0715 | 0.1232 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.479 | 0.8691 | 1 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0078 | 0.0066 | 0.0534 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0086 | 0.0081 | 0.0654 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0106 | 0.0117 | 0.0062 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0122 | 0.0147 | 0.0092 |
Brugia malayi | Kinesin motor domain containing protein | 0.0715 | 0.1232 | 1 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0715 | 0.1232 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0117 | 0.0316 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.