Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.002 | 0.0999 | 0.0999 |
Onchocerca volvulus | Putative nachr subunit | 0.002 | 0.0999 | 0.1544 |
Schistosoma mansoni | nAChR subunit | 0.002 | 0.0999 | 0.0999 |
Plasmodium falciparum | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0012 | 0.018 | 0.5 |
Mycobacterium tuberculosis | Probable amidase AmiC (aminohydrolase) | 0.0012 | 0.018 | 0.5 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.002 | 0.0999 | 0.0999 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0999 | 0.0999 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.002 | 0.0999 | 0.0999 |
Schistosoma mansoni | nAChR subunit | 0.002 | 0.0999 | 0.0999 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0012 | 0.018 | 0.018 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.009 | 0.8558 | 0.8558 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0999 | 0.0999 |
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.0012 | 0.018 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0999 | 0.0999 |
Brugia malayi | Cation transporter family protein | 0.002 | 0.0999 | 0.0999 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.002 | 0.0999 | 0.0999 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 1 | 1 |
Echinococcus multilocularis | nAChR subunit | 0.002 | 0.0999 | 0.0999 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.002 | 0.0999 | 0.0999 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0999 | 0.0999 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.002 | 0.0999 | 0.0999 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.002 | 0.0999 | 0.0999 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0999 | 0.0999 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.002 | 0.0999 | 0.0999 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0999 | 0.0999 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0999 | 0.0999 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.002 | 0.0999 | 0.0999 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0999 | 0.0999 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0103 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.009 | 0.8558 | 0.8558 |
Schistosoma mansoni | amidase | 0.0103 | 1 | 1 |
Trypanosoma cruzi | amidase, putative | 0.0012 | 0.018 | 0.5 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.002 | 0.0999 | 0.0999 |
Brugia malayi | bZIP transcription factor family protein | 0.009 | 0.8558 | 0.8558 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0012 | 0.018 | 0.5 |
Mycobacterium tuberculosis | Probable amidase AmiD (acylamidase) (acylase) | 0.0012 | 0.018 | 0.5 |
Brugia malayi | hypothetical protein | 0.0071 | 0.647 | 0.647 |
Mycobacterium tuberculosis | Probable amidase AmiA2 (aminohydrolase) | 0.0012 | 0.018 | 0.5 |
Onchocerca volvulus | 0.002 | 0.0999 | 0.1544 | |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.002 | 0.0999 | 0.0999 |
Schistosoma mansoni | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0012 | 0.018 | 0.018 |
Mycobacterium tuberculosis | Probable amidase AmiB2 (aminohydrolase) | 0.0012 | 0.018 | 0.5 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.002 | 0.0999 | 0.0999 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.002 | 0.0999 | 0.0999 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0012 | 0.018 | 0.018 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.002 | 0.0999 | 0.0999 |
Brugia malayi | Amidase family protein | 0.0012 | 0.018 | 0.018 |
Loa Loa (eye worm) | ACC-1 protein | 0.002 | 0.0999 | 0.0999 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.002 | 0.0999 | 0.0999 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.002 | 0.0999 | 0.0999 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.002 | 0.0999 | 0.0999 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0999 | 0.0999 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.002 | 0.0999 | 0.0999 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0999 | 0.0999 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.002 | 0.0999 | 0.0999 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.002 | 0.0999 | 0.0999 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0999 | 0.0999 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0999 | 0.0999 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0999 | 0.0999 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.002 | 0.0999 | 0.0999 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.002 | 0.0999 | 0.0999 |
Mycobacterium ulcerans | amidase | 0.0012 | 0.018 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0999 | 0.0999 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.002 | 0.0999 | 0.0999 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0103 | 1 | 1 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0012 | 0.018 | 0.5 |
Echinococcus multilocularis | glutamyl tRNA(Gln) amidotransferase subunit A | 0.0012 | 0.018 | 0.018 |
Mycobacterium ulcerans | amidase | 0.0012 | 0.018 | 0.5 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.002 | 0.0999 | 0.0999 |
Trypanosoma cruzi | amidase, putative | 0.0012 | 0.018 | 0.5 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.002 | 0.0999 | 0.0999 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0999 | 0.0999 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0999 | 0.0999 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.002 | 0.0999 | 0.0999 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0103 | 1 | 1 |
Onchocerca volvulus | 0.0071 | 0.647 | 1 | |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.002 | 0.0999 | 0.0999 |
Onchocerca volvulus | 0.002 | 0.0999 | 0.1544 | |
Loa Loa (eye worm) | amidase | 0.0012 | 0.018 | 0.018 |
Mycobacterium ulcerans | amidase | 0.0012 | 0.018 | 0.5 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.002 | 0.0999 | 0.0999 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0999 | 0.0999 |
Brugia malayi | Cation transporter family protein | 0.002 | 0.0999 | 0.0999 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.002 | 0.0999 | 0.0999 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.002 | 0.0999 | 0.0999 |
Onchocerca volvulus | 0.002 | 0.0999 | 0.1544 | |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0999 | 0.0999 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.002 | 0.0999 | 0.0999 |
Mycobacterium ulcerans | amidase | 0.0012 | 0.018 | 0.5 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.002 | 0.0999 | 0.0999 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.002 | 0.0999 | 0.0999 |
Echinococcus granulosus | nAChR subunit | 0.002 | 0.0999 | 0.0999 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.002 | 0.0999 | 0.0999 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.002 | 0.0999 | 0.0999 |
Brugia malayi | putative amidase | 0.0012 | 0.018 | 0.018 |
Plasmodium vivax | glutamyl-tRNA(Gln) amidotransferase subunit A, putative | 0.0012 | 0.018 | 0.5 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.002 | 0.0999 | 0.0999 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.002 | 0.0999 | 0.0999 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.002 | 0.0999 | 0.0999 |
Mycobacterium ulcerans | peptide amidase, GatA | 0.0012 | 0.018 | 0.5 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.002 | 0.0999 | 0.0999 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0012 | 0.018 | 0.018 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.002 | 0.0999 | 0.0999 |
Onchocerca volvulus | 0.002 | 0.0999 | 0.1544 | |
Leishmania major | hypothetical protein, conserved | 0.0012 | 0.018 | 0.5 |
Schistosoma mansoni | jun-related protein | 0.0073 | 0.6736 | 0.6736 |
Echinococcus granulosus | glutamyl tRNAGln amidotransferase subunit A | 0.0012 | 0.018 | 0.018 |
Loa Loa (eye worm) | LGC-31 protein | 0.002 | 0.0999 | 0.0999 |
Schistosoma mansoni | nAChR subunit | 0.002 | 0.0999 | 0.0999 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.002 | 0.0999 | 0.0999 |
Echinococcus granulosus | glycine receptor subunit beta | 0.002 | 0.0999 | 0.0999 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0012 | 0.018 | 0.5 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.002 | 0.0999 | 0.0999 |
Echinococcus granulosus | glycine receptor subunit beta | 0.002 | 0.0999 | 0.0999 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.6736 | 0.6736 |
Loa Loa (eye worm) | ACC-1 protein | 0.002 | 0.0999 | 0.0999 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.002 | 0.0999 | 0.0999 |
Echinococcus granulosus | jun protein | 0.009 | 0.8558 | 0.8558 |
Schistosoma mansoni | nAChR subunit | 0.002 | 0.0999 | 0.0999 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.002 | 0.0999 | 0.0999 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.002 | 0.0999 | 0.0999 |
Schistosoma mansoni | nAChR subunit | 0.002 | 0.0999 | 0.0999 |
Mycobacterium ulcerans | amidase | 0.0012 | 0.018 | 0.5 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.002 | 0.0999 | 0.0999 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0999 | 0.0999 |
Trypanosoma brucei | fatty-acid amide hydrolase, putative | 0.0012 | 0.018 | 0.5 |
Brugia malayi | Amidase family protein | 0.0012 | 0.018 | 0.018 |
Echinococcus multilocularis | jun protein | 0.009 | 0.8558 | 0.8558 |
Loa Loa (eye worm) | amidase | 0.0012 | 0.018 | 0.018 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.002 | 0.0999 | 0.0999 |
Mycobacterium tuberculosis | Possible amidase (aminohydrolase) | 0.0012 | 0.018 | 0.5 |
Onchocerca volvulus | 0.002 | 0.0999 | 0.1544 | |
Mycobacterium ulcerans | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0012 | 0.018 | 0.5 |
Schistosoma mansoni | nAChR subunit | 0.002 | 0.0999 | 0.0999 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.002 | 0.0999 | 0.0999 |
Schistosoma mansoni | nAChR subunit | 0.002 | 0.0999 | 0.0999 |
Entamoeba histolytica | hypothetical protein | 0.0011 | 0 | 0.5 |
Onchocerca volvulus | 0.002 | 0.0999 | 0.1544 | |
Brugia malayi | Cation transporter family protein | 0.002 | 0.0999 | 0.0999 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.002 | 0.0999 | 0.0999 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.002 | 0.0999 | 0.0999 |
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.0012 | 0.018 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.8292 | 0.8292 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.002 | 0.0999 | 0.0999 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.002 | 0.0999 | 0.0999 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 62 ug ml-1 | In vitro Minimum inhibitory concentration (MIC) for antifungal activity against Candida albicans 1208E | ChEMBL. | 11755334 |
MIC (functional) | = 62 ug ml-1 | In vitro Minimum inhibitory concentration (MIC) for antifungal activity against Candida albicans 2005E | ChEMBL. | 11755334 |
MIC (functional) | > 62 ug ml-1 | In vitro Minimum inhibitory concentration (MIC) for antifungal activity against Candida albicans 2402E | ChEMBL. | 11755334 |
MIC (functional) | > 62 ug ml-1 | In vitro Minimum inhibitory concentration (MIC) for antifungal activity against Candida pseudotropicalis 2371E | ChEMBL. | 11755334 |
MIC (functional) | > 62 ug ml-1 | In vitro Minimum inhibitory concentration (MIC) for antifungal activity against Candida tropicalis 2808E | ChEMBL. | 11755334 |
MIC (functional) | > 62 ug ml-1 | In vitro Minimum inhibitory concentration (MIC) for antifungal activity against Cryptococcus neoformans 2867E | ChEMBL. | 11755334 |
MIC (functional) | > 62 ug ml-1 | In vitro Minimum inhibitory concentration (MIC) for antifungal activity against Candida albicans 1208E | ChEMBL. | 11755334 |
MIC (functional) | = 62 ug ml-1 | In vitro Minimum inhibitory concentration (MIC) for antifungal activity against Candida albicans 2005E | ChEMBL. | 11755334 |
MIC (functional) | > 62 ug ml-1 | In vitro Minimum inhibitory concentration (MIC) for antifungal activity against Candida albicans 2402E | ChEMBL. | 11755334 |
MIC (functional) | > 62 ug ml-1 | In vitro Minimum inhibitory concentration (MIC) for antifungal activity against Cryptococcus neoformans 2867E | ChEMBL. | 11755334 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.