Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | trypanothione reductase, putative | 0.0176 | 0.9881 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0051 | 0.1219 | 0.5 |
Leishmania major | trypanothione reductase | 0.0176 | 0.9881 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0176 | 0.9881 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0176 | 0.9881 | 1 |
Treponema pallidum | NADH oxidase | 0.0051 | 0.1219 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0176 | 0.9881 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0051 | 0.1219 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0178 | 1 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0051 | 0.1219 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0176 | 0.9881 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0176 | 0.9881 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0051 | 0.1219 | 0.5 |
Brugia malayi | glutathione reductase | 0.0176 | 0.9881 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0051 | 0.1219 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0176 | 0.9881 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0051 | 0.1219 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0051 | 0.1219 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0051 | 0.1219 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0176 | 0.9881 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0176 | 0.9881 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0051 | 0.1219 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0176 | 0.9881 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0051 | 0.1219 | 0.5 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0051 | 0.1219 | 0.1234 |
Loa Loa (eye worm) | glutathione reductase | 0.0176 | 0.9881 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.