Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | epoxide hydrolase EphA | 0.0109 | 0.7735 | 0.5 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0037 | 0 | 0.5 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0037 | 0 | 0.5 |
Giardia lamblia | Kinase, CMGC CDK | 0.0037 | 0 | 0.5 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0037 | 0 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.013 | 1 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0106 | 0.7418 | 1 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0037 | 0 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0106 | 0.7418 | 1 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.0043 | 0.068 | 0.068 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0037 | 0 | 0.5 |
Onchocerca volvulus | 0.0106 | 0.7418 | 0.5 | |
Schistosoma mansoni | sodium-bile acid cotransporter | 0.0063 | 0.2822 | 0.2822 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0106 | 0.7418 | 1 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0106 | 0.7418 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.013 | 1 | 1 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.0106 | 0.7418 | 0.7418 |
Mycobacterium tuberculosis | Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) | 0.0109 | 0.7735 | 0.5 |
Plasmodium falciparum | protein kinase 5 | 0.0037 | 0 | 0.5 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0106 | 0.7418 | 1 |
Brugia malayi | Sodium Bile acid symporter family protein | 0.0106 | 0.7418 | 0.7418 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0037 | 0 | 0.5 |
Plasmodium vivax | protein kinase Crk2 | 0.0037 | 0 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0037 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0106 | 0.7418 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0037 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.7418 | 0.7418 |
Giardia lamblia | Kinase, CMGC CDK | 0.0037 | 0 | 0.5 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0037 | 0 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0037 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.