Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0021 | 0 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0249 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.4664 | 0.4327 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0249 | 1 | 0.5 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | hedgehog | 0.0127 | 0.4637 | 0.3678 |
Loa Loa (eye worm) | acetyltransferase | 0.0071 | 0.2196 | 0.1704 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0222 | 0.8832 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0222 | 0.8832 | 0.8759 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0069 | 0.2109 | 0.2388 |
Schistosoma mansoni | hypothetical protein | 0.0092 | 0.3129 | 0.1406 |
Echinococcus granulosus | Desert hedgehog protein | 0.0127 | 0.4637 | 0.525 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0071 | 0.2196 | 0.1704 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0222 | 0.8832 | 0.8759 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0222 | 0.8832 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 1 | 1 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0222 | 0.8832 | 1 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0021 | 0 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0249 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.