Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | chitinase/cellulase | 0.0155 | 0 | 0.5 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0155 | 0 | 0.5 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0173 | 0.3655 | 0.5759 |
Onchocerca volvulus | Putative endochitinase | 0.0204 | 1 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.0204 | 1 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.0204 | 1 | 1 |
Loa Loa (eye worm) | chitinase I | 0.0186 | 0.6345 | 1 |
Loa Loa (eye worm) | cuticular endochitinase | 0.0186 | 0.6345 | 1 |
Entamoeba histolytica | chitinase, putative | 0.0186 | 0.6345 | 0.5 |
Leishmania major | chitinase | 0.0186 | 0.6345 | 0.5 |
Brugia malayi | Endochitinase | 0.0204 | 1 | 1 |
Mycobacterium tuberculosis | Possible chitinase | 0.0155 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.