Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0119 | 0.2109 | 0.2388 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 0.4664 | 0.4327 |
Schistosoma mansoni | hypothetical protein | 0.0159 | 0.3129 | 0.1406 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0384 | 0.8832 | 0.8759 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0123 | 0.2196 | 0.1704 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0384 | 0.8832 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.043 | 1 | 0.5 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.043 | 1 | 1 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0384 | 0.8832 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.043 | 1 | 0.5 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0036 | 0 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.043 | 1 | 0.5 |
Echinococcus multilocularis | hedgehog | 0.0219 | 0.4637 | 0.3678 |
Echinococcus granulosus | Desert hedgehog protein | 0.0219 | 0.4637 | 0.525 |
Loa Loa (eye worm) | acetyltransferase | 0.0123 | 0.2196 | 0.1704 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0384 | 0.8832 | 0.8759 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0384 | 0.8832 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.