Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glutamate receptor | 0.0164 | 0.0238 | 0.0247 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.035 | 0.5219 | 0.5219 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0155 | 0 | 0.5 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0418 | 0.7038 | 0.7038 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0155 | 0 | 0.5 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0155 | 0 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0475 | 0.8574 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0204 | 0.1292 | 0.1507 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0514 | 0.9628 | 0.9628 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0155 | 0 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0155 | 0 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0155 | 0 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.0528 | 1 | 1 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0155 | 0 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0155 | 0 | 0.5 |
Onchocerca volvulus | 0.0528 | 1 | 1 | |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0378 | 0.5984 | 0.5984 |
Entamoeba histolytica | aminopeptidase, putative | 0.0155 | 0 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0514 | 0.9628 | 0.9628 |
Loa Loa (eye worm) | hypothetical protein | 0.0514 | 0.9628 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0474 | 0.8533 | 0.8863 |
Echinococcus granulosus | aminopeptidase N | 0.0528 | 1 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0155 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0155 | 0 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.035 | 0.5219 | 0.6086 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0204 | 0.1292 | 0.1292 |
Loa Loa (eye worm) | hypothetical protein | 0.0373 | 0.5828 | 0.6053 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0155 | 0 | 0.5 |
Loa Loa (eye worm) | glutamate receptor | 0.0418 | 0.7038 | 0.731 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.035 | 0.5219 | 0.5219 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0427 | 0.7295 | 0.7577 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.