Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0967 | 1 |
Trypanosoma brucei | beta lactamase | 0.0335 | 0.4564 | 0.5 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0095 | 0.0967 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0095 | 0.0967 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqF | 0.0335 | 0.4564 | 0.3629 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0088 | 0.0859 | 1 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.007 | 0.0592 | 0.8166 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0065 | 0.0513 | 0.5392 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.0697 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0077 | 0.0701 | 0.7241 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0077 | 0.0701 | 1 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.0335 | 0.4564 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.