Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Aph-1 protein, putative | 0.0219 | 0.3742 | 1 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.0562 | 1 | 0.5 |
Trypanosoma brucei | Aph-1 protein, putative | 0.0219 | 0.3742 | 1 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.0562 | 1 | 0.5 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0562 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0014 | 0 | 0.5 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.0562 | 1 | 0.5 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0219 | 0.3742 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0014 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.