Detailed information for compound 2073912

Basic information

Technical information
  • TDR Targets ID: 2073912
  • Name: 2-(dimethylaminomethyl)-7-methoxy-3,4-dihydro -2H-naphthalen-1-one
  • MW: 233.306 | Formula: C14H19NO2
  • H donors: 0 H acceptors: 1 LogP: 2.07 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)C(=O)C(CC2)CN(C)C
  • InChi: 1S/C14H19NO2/c1-15(2)9-11-5-4-10-6-7-12(17-3)8-13(10)14(11)16/h6-8,11H,4-5,9H2,1-3H3
  • InChiKey: JYARBGGPLKDNRV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(dimethylaminomethyl)-7-methoxy-tetralin-1-one
  • 2-(dimethylaminomethyl)-7-methoxy-1-tetralinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi G-protein coupled receptor 0.0166 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0166 0 0.5
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0166 0 0.5
Brugia malayi G protein-coupled receptor F59B2.13 0.0166 0 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.0166 0 0.5
Brugia malayi larval opioid receptor 0.0166 0 0.5
Schistosoma mansoni amine GPCR 0.0166 0 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0166 0 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0166 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0166 0 0.5
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0166 0 0.5
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0166 0 0.5
Brugia malayi neuropeptide F receptor 0.0166 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0166 0 0.5
Schistosoma mansoni amine GPCR 0.0166 0 0.5
Echinococcus granulosus peptide allatostatin:somatostatin 0.0166 0 0.5
Schistosoma mansoni histamine h1 receptor 0.0166 0 0.5
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0166 0 0.5
Brugia malayi Dopamine receptor protein 2 0.0166 0 0.5
Brugia malayi G protein-coupled receptor 0.0166 0 0.5
Echinococcus granulosus serotonin receptor 0.0166 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0166 0 0.5
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0166 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0166 0 0.5
Schistosoma mansoni biogenic amine receptor 0.0166 0 0.5
Brugia malayi hypothetical protein 0.0166 0 0.5
Brugia malayi Dopamine receptor 0.0166 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0166 0 0.5
Brugia malayi Dopamine receptor protein 1 0.0166 0 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0166 0 0.5
Brugia malayi Serotonin receptor 0.0166 0 0.5
Echinococcus granulosus 7tm_1 domain containing protein 0.0166 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0166 0 0.5
Echinococcus multilocularis neuropeptide receptor 0.0166 0 0.5
Echinococcus granulosus g protein coupled receptor 0.0166 0 0.5
Brugia malayi AKH receptor 0.0166 0 0.5
Schistosoma mansoni hypothetical protein 0.0166 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0166 0 0.5
Brugia malayi Serotonin receptor 0.0166 0 0.5
Schistosoma mansoni amine GPCR 0.0166 0 0.5
Echinococcus multilocularis g-protein coupled receptor 0.0166 0 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.0166 0 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0166 0 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0166 0 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0166 0 0.5
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0166 0 0.5
Schistosoma mansoni myosin xvIII 0.0166 0 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0166 0 0.5
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0166 0 0.5
Schistosoma mansoni neuropeptide receptor 0.0166 0 0.5
Schistosoma mansoni opsin-like receptor 0.0166 0 0.5
Schistosoma mansoni amine GPCR 0.0166 0 0.5
Brugia malayi sulfakinin receptor protein 0.0166 0 0.5
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0166 0 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0166 0 0.5
Schistosoma mansoni neuropeptide receptor 0.0166 0 0.5
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0166 0 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0166 0 0.5
Schistosoma mansoni biogenic amine receptor 0.0166 0 0.5
Echinococcus granulosus 7TM GPCR rhodopsin 0.0166 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0166 0 0.5
Brugia malayi neuropeptide F receptor 0.0166 0 0.5
Echinococcus multilocularis serotonin receptor 0.0166 0 0.5
Brugia malayi hypothetical protein 0.0166 0 0.5
Echinococcus granulosus G protein coupled receptor 139 0.0166 0 0.5
Schistosoma mansoni neuropeptide receptor 0.0166 0 0.5
Echinococcus multilocularis g protein coupled receptor 0.0166 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0166 0 0.5
Brugia malayi hypothetical protein 0.0166 0 0.5
Echinococcus granulosus somatostatin receptor 0.0166 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0166 0 0.5
Brugia malayi Tachykinin-like peptides receptor 99D 0.0166 0 0.5
Echinococcus multilocularis G-protein coupled receptor, putative 0.0166 0 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0166 0 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0166 0 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0166 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0166 0 0.5
Echinococcus granulosus sex peptide receptor 0.0166 0 0.5
Schistosoma mansoni hypothetical protein 0.0166 0 0.5
Echinococcus multilocularis g protein coupled receptor 0.0166 0 0.5
Schistosoma mansoni hypothetical protein 0.0166 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0166 0 0.5
Echinococcus multilocularis fmrfamide receptor 0.0166 0 0.5
Brugia malayi Melatonin receptor type 1A 0.0166 0 0.5
Schistosoma mansoni hypothetical protein 0.0166 0 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0166 0 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0166 0 0.5
Schistosoma mansoni growth hormone secretagogue receptor 0.0166 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0166 0 0.5
Echinococcus multilocularis neuropeptide receptor 0.0166 0 0.5
Echinococcus granulosus neuropeptide receptor A26 0.0166 0 0.5
Schistosoma mansoni amine GPCR 0.0166 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0166 0 0.5
Echinococcus granulosus dro:myosuppressin receptor 0.0166 0 0.5
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0166 0 0.5
Echinococcus multilocularis sex peptide receptor 0.0166 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0166 0 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0166 0 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0166 0 0.5
Echinococcus granulosus hypothetical protein 0.0166 0 0.5
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0166 0 0.5
Echinococcus multilocularis neuropeptide s receptor 0.0166 0 0.5
Schistosoma mansoni adenoreceptor 0.0166 0 0.5
Loa Loa (eye worm) hypothetical protein 0.025 0.9554 1
Echinococcus multilocularis neuropeptide receptor A26 0.0166 0 0.5
Schistosoma mansoni opsin-like receptor 0.0166 0 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0166 0 0.5
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0166 0 0.5
Echinococcus granulosus neuropeptide FF receptor 2 0.0166 0 0.5
Brugia malayi RE15519p 0.0166 0 0.5
Brugia malayi hypothetical protein 0.0166 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0166 0 0.5
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0166 0 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0166 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0166 0 0.5
Brugia malayi G-protein coupled receptor 0.0166 0 0.5
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0166 0 0.5
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0166 0 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0166 0 0.5
Echinococcus multilocularis allatostatin A receptor 0.0166 0 0.5
Echinococcus multilocularis G protein coupled receptor 139 0.0166 0 0.5
Echinococcus granulosus g protein coupled receptor 0.0166 0 0.5
Brugia malayi ORL1-like opioid receptor 0.0166 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0166 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0166 0 0.5
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0166 0 0.5
Echinococcus granulosus neuropeptide s receptor 0.0166 0 0.5
Brugia malayi hypothetical protein 0.0166 0 0.5
Brugia malayi hypothetical protein 0.0166 0 0.5
Echinococcus multilocularis serotonin receptor 0.0166 0 0.5
Brugia malayi GnHR receptor homolog 0.0166 0 0.5
Echinococcus granulosus tachykinin peptides receptor 99D 0.0166 0 0.5
Brugia malayi hypothetical protein 0.0166 0 0.5
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0166 0 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0166 0 0.5
Echinococcus granulosus neuropeptide receptor 0.0166 0 0.5
Echinococcus granulosus orexin receptor type 2 0.0166 0 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0166 0 0.5
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0166 0 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0166 0 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0166 0 0.5
Echinococcus multilocularis dro:myosuppressin receptor 0.0166 0 0.5
Echinococcus granulosus fmrfamide receptor 0.0166 0 0.5
Echinococcus granulosus g protein coupled receptor 0.0166 0 0.5
Schistosoma mansoni biogenic amine receptor 0.0166 0 0.5
Echinococcus multilocularis g protein coupled receptor 0.0166 0 0.5
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0166 0 0.5
Echinococcus multilocularis neuropeptide FF receptor 2 0.0166 0 0.5
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0166 0 0.5
Schistosoma mansoni opsin-like receptor 0.0166 0 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0166 0 0.5
Echinococcus multilocularis orexin receptor type 2 0.0166 0 0.5
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0166 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0166 0 0.5
Echinococcus multilocularis fmrfamide receptor 0.0166 0 0.5
Echinococcus granulosus alpha 1A adrenergic receptor 0.0166 0 0.5
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0166 0 0.5
Echinococcus granulosus allatostatin A receptor 0.0166 0 0.5
Brugia malayi putative neuropeptide receptor NPR1 0.0166 0 0.5
Brugia malayi hypothetical protein 0.0166 0 0.5
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0166 0 0.5
Brugia malayi hypothetical protein 0.0166 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0166 0 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0166 0 0.5
Schistosoma mansoni neuropeptide f receptor 76f 0.0166 0 0.5
Schistosoma mansoni alpha-1 adrenergic receptor 0.0166 0 0.5
Brugia malayi hypothetical protein 0.0166 0 0.5
Schistosoma mansoni neuropeptide receptor 0.0166 0 0.5
Brugia malayi putative neuropeptide receptor 0.0166 0 0.5
Echinococcus multilocularis somatostatin receptor 0.0166 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0166 0 0.5
Brugia malayi follicle stimulating hormone receptor 0.0166 0 0.5
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0166 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0166 0 0.5
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0166 0 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0166 0 0.5
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0166 0 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0166 0 0.5
Echinococcus granulosus neuropeptide receptor 0.0166 0 0.5
Echinococcus granulosus g-protein coupled receptor 0.0166 0 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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