Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | caspase | 0.0114 | 0.0494 | 0.0494 |
Plasmodium falciparum | kinesin-5 | 0.0091 | 0.0122 | 0.5 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0091 | 0.0122 | 0.5 |
Echinococcus multilocularis | kinesin family 1 | 0.07 | 1 | 1 |
Plasmodium vivax | kinesin-5 | 0.0091 | 0.0122 | 0.5 |
Entamoeba histolytica | kinesin, putative | 0.0091 | 0.0122 | 0.5 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0091 | 0.0122 | 0.5 |
Giardia lamblia | Kinesin-5 | 0.0091 | 0.0122 | 0.5 |
Brugia malayi | Kinesin motor domain containing protein | 0.0091 | 0.0122 | 0.5 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0114 | 0.0494 | 0.0494 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.0114 | 0.0494 | 0.0494 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0114 | 0.0494 | 0.0443 |
Echinococcus granulosus | caspase | 0.0114 | 0.0494 | 0.0494 |
Schistosoma mansoni | hypothetical protein | 0.0609 | 0.8525 | 1 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0114 | 0.0494 | 0.0443 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.