Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0087 | 0.1821 | 0.1821 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.6214 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0045 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.013 | 0.3691 | 1 |
Brugia malayi | TAR-binding protein | 0.013 | 0.3691 | 0.3691 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.013 | 0.3691 | 0.3691 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0094 | 0.2121 | 0.0683 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0274 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0094 | 0.2121 | 0.2121 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0094 | 0.2121 | 0.1604 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0045 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.3691 | 0.4256 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.3691 | 0.4256 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0045 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0094 | 0.2121 | 0.1604 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0094 | 0.2121 | 0.2121 |
Brugia malayi | RNA binding protein | 0.013 | 0.3691 | 0.3691 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0094 | 0.2121 | 0.0683 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0045 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.6214 | 0.6214 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.3691 | 0.4256 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.3691 | 0.4256 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0045 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0094 | 0.2121 | 0.1604 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0094 | 0.2121 | 0.1604 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.1821 | 0.1821 |
Leishmania major | hypothetical protein, conserved | 0.0045 | 0 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0188 | 0.6214 | 0.6214 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0274 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.013 | 0.3691 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0087 | 0.1821 | 0.1821 |
Loa Loa (eye worm) | RNA binding protein | 0.013 | 0.3691 | 0.3691 |
Brugia malayi | RNA recognition motif domain containing protein | 0.013 | 0.3691 | 0.3691 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0094 | 0.2121 | 0.0683 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.3691 | 0.4256 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0087 | 0.1821 | 0.1821 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.013 | 0.3691 | 0.3691 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0045 | 0 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0045 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.