Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | peroxidasin | 0.0739 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0739 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0739 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0739 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0739 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0739 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0739 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0739 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0739 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0739 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0739 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0739 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0739 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0739 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0739 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0739 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0739 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0739 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0739 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0739 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0739 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0739 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0739 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0739 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0739 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0739 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0739 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0739 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0739 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0739 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0739 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0739 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0739 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0739 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0739 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0739 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0739 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0739 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0739 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 20 % | In vitro effect on the proliferation of B lymphocytes of mouse splenocytes at 20 umol/L to show the antibody formation by [3H]-thymidine incorporation | ChEMBL. | 12443772 |
Activity (functional) | = 38 % | In vitro effect on the proliferation of T lymphocytes of mouse splenocytes at 20 umol/L to show the cell-mediated immunity by [3H]-thymidine incorporation | ChEMBL. | 12443772 |
Activity (functional) | = 62 % | In vitro effect on the proliferation of T lymphocytes of mouse splenocytes at 2 umol/L to show the cell-mediated immunity by [3H]-thymidine incorporation | ChEMBL. | 12443772 |
Activity (functional) | = 69 % | In vitro effect on the proliferation of B lymphocytes of mouse splenocytes at 2.0 umol/L to show the antibody formation by [3H]-thymidine incorporation | ChEMBL. | 12443772 |
Activity (functional) | = 80 % | In vitro effect on the proliferation of T lymphocytes of mouse splenocytes at 0.2 umol/L to show the cell-mediated immunity by [3H]-thymidine incorporation | ChEMBL. | 12443772 |
Activity (functional) | = 96 % | In vitro effect on the proliferation of B lymphocytes of mouse splenocytes at 0.2 umol/L to show the antibody formation by [3H]-thymidine incorporation | ChEMBL. | 12443772 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.