Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Aldose reductase | 0.0745 | 1 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0745 | 1 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0529 | 0.6557 | 0.5922 |
Loa Loa (eye worm) | oxidoreductase | 0.0745 | 1 | 1 |
Onchocerca volvulus | 0.0745 | 1 | 1 | |
Loa Loa (eye worm) | oxidoreductase | 0.0745 | 1 | 1 |
Leishmania major | aldo-keto reductase-like protein | 0.0745 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0745 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0745 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0745 | 1 | 1 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0745 | 1 | 1 |
Echinococcus multilocularis | voltage gated potassium channel subunit | 0.0216 | 0.1556 | 0.1556 |
Plasmodium falciparum | aldo-keto reductase, putative | 0.0216 | 0.1556 | 0.5 |
Trypanosoma brucei | prostaglandin f synthase | 0.0745 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0745 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0745 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0745 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0745 | 1 | 0.5 |
Brugia malayi | glutamate-cysteine ligase modifier subunit | 0.0216 | 0.1556 | 0.1012 |
Echinococcus multilocularis | aldo keto reductase | 0.0745 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0745 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0745 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0745 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Loa Loa (eye worm) | glutamate-cysteine ligase modifier subunit | 0.0216 | 0.1556 | 0.1012 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0745 | 1 | 1 |
Onchocerca volvulus | 0.0745 | 1 | 1 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Plasmodium vivax | aldehyde reductase, putative | 0.0216 | 0.1556 | 0.5 |
Mycobacterium ulcerans | oxidoreductase | 0.0745 | 1 | 1 |
Schistosoma mansoni | pol-related | 0.0745 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0745 | 1 | 1 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0745 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0745 | 1 | 1 |
Onchocerca volvulus | 0.0745 | 1 | 1 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0156 | 0.0605 | 0.0605 |
Trypanosoma cruzi | aldo-keto reductase | 0.0745 | 1 | 1 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0745 | 1 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0156 | 0.0605 | 0.0605 |
Echinococcus granulosus | aldehyde reductase | 0.0529 | 0.6557 | 0.6557 |
Onchocerca volvulus | 0.0745 | 1 | 1 | |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0745 | 1 | 1 |
Toxoplasma gondii | aldose reductase, putative | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0745 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0745 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0745 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Echinococcus granulosus | hypothetical protein | 0.0745 | 1 | 1 |
Leishmania major | prostaglandin f synthase, putative | 0.0745 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0745 | 1 | 1 |
Onchocerca volvulus | 0.0745 | 1 | 1 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0745 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0745 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0156 | 0.0605 | 0.0605 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0745 | 1 | 1 |
Brugia malayi | NADH-dependent xylose reductase | 0.0216 | 0.1556 | 0.1012 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0745 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0745 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0745 | 1 | 1 |
Onchocerca volvulus | 0.0745 | 1 | 1 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldehyde reductase | 0.0529 | 0.6557 | 0.6557 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0745 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0745 | 1 | 1 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0745 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0745 | 1 | 1 |
Schistosoma mansoni | potassium channel beta | 0.0216 | 0.1556 | 0.1556 |
Entamoeba histolytica | aldose reductase, putative | 0.0745 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0745 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0745 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0745 | 1 | 1 |
Echinococcus granulosus | voltage gated potassium channel subunit | 0.0216 | 0.1556 | 0.1556 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0745 | 1 | 1 |
Plasmodium falciparum | aldehyde reductase, putative | 0.0216 | 0.1556 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1, member B4 | 0.0216 | 0.1556 | 0.1556 |
Plasmodium vivax | oxidoreductase, aldo/keto reductase domain containing protein | 0.0216 | 0.1556 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0745 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0745 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Km (binding) | = 85 uM | Compound was evaluated in vitro for its inhibitory effect Vitamin K dependent carboxylase of Phe-Leu-Glu-Glu-Leu in rat microsomal protein | ChEMBL. | 6332196 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.