Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0398 | 0.0413 | 0.0413 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0758 | 0.5206 | 0.5206 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0758 | 0.5206 | 0.5206 |
Echinococcus granulosus | glutamate receptor NMDA | 0.067 | 0.4039 | 0.4039 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0398 | 0.0413 | 0.0413 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.1119 | 1 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.1037 | 0.8911 | 1 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.067 | 0.4039 | 0.4039 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0448 | 0.1089 | 0.1089 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 4 uM | In vitro antitumor effects against human T-47D cell lines. | ChEMBL. | 12877592 |
IC50 (functional) | = 4 uM | In vitro antitumor effects against human T-47D cell lines. | ChEMBL. | 12877592 |
IC50 (functional) | = 5 uM | In vitro antitumor effects against human SW 1088 cell lines. | ChEMBL. | 12877592 |
IC50 (functional) | = 5 uM | In vitro antitumor effects against human J82 cell lines. | ChEMBL. | 12877592 |
IC50 (functional) | = 5 uM | In vitro antitumor effects against human HCT-15 cell lines. | ChEMBL. | 12877592 |
IC50 (functional) | = 5 uM | In vitro antitumor effects against human LoVo cell lines. | ChEMBL. | 12877592 |
IC50 (functional) | = 5 uM | In vitro antitumor effects against human SW 1088 cell lines. | ChEMBL. | 12877592 |
IC50 (functional) | = 5 uM | In vitro antitumor effects against human J82 cell lines. | ChEMBL. | 12877592 |
IC50 (functional) | = 5 uM | In vitro antitumor effects against human HCT-15 cell lines. | ChEMBL. | 12877592 |
IC50 (functional) | = 5 uM | In vitro antitumor effects against human LoVo cell lines. | ChEMBL. | 12877592 |
IC50 (functional) | = 6 uM | In vitro antitumor effects against human U87MG cell lines. | ChEMBL. | 12877592 |
IC50 (functional) | = 6 uM | In vitro antitumor effects against human U-373MG cell lines. | ChEMBL. | 12877592 |
IC50 (functional) | = 6 uM | In vitro antitumor effects against human T24 cell lines. | ChEMBL. | 12877592 |
IC50 (functional) | = 6 uM | In vitro antitumor effects against human MCF-7 cell lines. | ChEMBL. | 12877592 |
IC50 (functional) | = 6 uM | In vitro antitumor effects against human A-427 cell lines. | ChEMBL. | 12877592 |
IC50 (functional) | = 6 uM | In vitro antitumor effects against human U87MG cell lines. | ChEMBL. | 12877592 |
IC50 (functional) | = 6 uM | In vitro antitumor effects against human U-373MG cell lines. | ChEMBL. | 12877592 |
IC50 (functional) | = 6 uM | In vitro antitumor effects against human T24 cell lines. | ChEMBL. | 12877592 |
IC50 (functional) | = 6 uM | In vitro antitumor effects against human MCF-7 cell lines. | ChEMBL. | 12877592 |
IC50 (functional) | = 6 uM | In vitro antitumor effects against human A-427 cell lines. | ChEMBL. | 12877592 |
IC50 (functional) | > 10 uM | In vitro antitumor effects against human A-549 cell lines. | ChEMBL. | 12877592 |
IC50 (functional) | > 10 uM | In vitro antitumor effects against human PC-3 cell lines. | ChEMBL. | 12877592 |
IC50 (functional) | > 10 uM | In vitro antitumor effects against human A-549 cell lines. | ChEMBL. | 12877592 |
IC50 (functional) | > 10 uM | In vitro antitumor effects against human PC-3 cell lines. | ChEMBL. | 12877592 |
MTD (functional) | = 40 mg kg-1 | Maximum tolerated dose following single i.p. injection to B6D2F1/jico mice. | ChEMBL. | 12877592 |
MTD (functional) | = 40 mg kg-1 | Maximum tolerated dose following single i.p. injection to B6D2F1/jico mice. | ChEMBL. | 12877592 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 12877592 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.