Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2597 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.2597 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2597 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2597 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2597 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2597 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2597 | 1 | 1 |
Echinococcus granulosus | hypothetical protein | 0.2597 | 1 | 1 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.2597 | 1 | 0.5 |
Onchocerca volvulus | 0.2597 | 1 | 0.5 | |
Echinococcus granulosus | aldo keto reductase | 0.2597 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2597 | 1 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.2597 | 1 | 0.5 |
Trypanosoma cruzi | aldo-keto reductase | 0.2597 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.2597 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.2597 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2597 | 1 | 1 |
Onchocerca volvulus | 0.2597 | 1 | 0.5 | |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.2597 | 1 | 0.5 |
Giardia lamblia | Aldose reductase | 0.2597 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.2597 | 1 | 0.5 |
Onchocerca volvulus | 0.2597 | 1 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2597 | 1 | 0.5 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.2597 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.2597 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2597 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2597 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2597 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2597 | 1 | 0.5 |
Onchocerca volvulus | 0.2597 | 1 | 0.5 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2597 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2597 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.2597 | 1 | 0.5 |
Onchocerca volvulus | 0.2597 | 1 | 0.5 | |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.2597 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2597 | 1 | 1 |
Toxoplasma gondii | aldose reductase, putative | 0.2597 | 1 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.2597 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2597 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2597 | 1 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.2597 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2597 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2597 | 1 | 1 |
Leishmania major | prostaglandin f synthase, putative | 0.2597 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.2597 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2597 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.2597 | 1 | 0.5 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.2597 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.2597 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2597 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.2597 | 1 | 0.5 |
Trypanosoma brucei | prostaglandin f synthase | 0.2597 | 1 | 0.5 |
Giardia lamblia | Aldose reductase | 0.2597 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2597 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.2597 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2597 | 1 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.2597 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2597 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2597 | 1 | 1 |
Onchocerca volvulus | 0.2597 | 1 | 0.5 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2597 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2597 | 1 | 1 |
Schistosoma mansoni | pol-related | 0.2597 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.2597 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2597 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.2597 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.2597 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2597 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.2597 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.2597 | 1 | 0.5 |
Leishmania major | aldo-keto reductase-like protein | 0.2597 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2597 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2597 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.2597 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2597 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.2597 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.2597 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.2597 | 1 | 0.5 |
Mycobacterium ulcerans | oxidoreductase | 0.2597 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.2597 | 1 | 1 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.2597 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 0 % | Percentage of inhibition of Prostaglandin G/H synthase 1 activity in human whole blood (HWB) at 10 microM | ChEMBL. | 11462976 |
Inhibition (binding) | = 0 % | Percentage of inhibition of Prostaglandin G/H synthase 1 activity in human whole blood (HWB) at 10 microM | ChEMBL. | 11462976 |
Inhibition (binding) | = 4.3 % | Percentage inhibition of Prostaglandin G/H synthase 2 activity in human whole blood (HWB) at 10 microM | ChEMBL. | 11462976 |
Inhibition (binding) | = 4.3 % | Percentage inhibition of Prostaglandin G/H synthase 2 activity in human whole blood (HWB) at 10 microM | ChEMBL. | 11462976 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.