Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aldo keto reductase | 0.203 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.203 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.203 | 1 | 0.5 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.203 | 1 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.203 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.203 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.203 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.203 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.203 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.203 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.203 | 1 | 0.5 |
Onchocerca volvulus | 0.203 | 1 | 0.5 | |
Onchocerca volvulus | 0.203 | 1 | 0.5 | |
Echinococcus multilocularis | aldo keto reductase | 0.203 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.203 | 1 | 0.5 |
Onchocerca volvulus | 0.203 | 1 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.203 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.203 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.203 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.203 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.203 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.203 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.203 | 1 | 0.5 |
Leishmania major | prostaglandin f synthase, putative | 0.203 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.203 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.203 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.203 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.203 | 1 | 1 |
Trypanosoma cruzi | aldo-keto reductase | 0.203 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.203 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.203 | 1 | 1 |
Onchocerca volvulus | 0.203 | 1 | 0.5 | |
Loa Loa (eye worm) | oxidoreductase | 0.203 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.203 | 1 | 0.5 |
Leishmania major | aldo-keto reductase-like protein | 0.203 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.203 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.203 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.203 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.203 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.203 | 1 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.203 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.203 | 1 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.203 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.203 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.203 | 1 | 1 |
Echinococcus granulosus | hypothetical protein | 0.203 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.203 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.203 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.203 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.203 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.203 | 1 | 0.5 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.203 | 1 | 0.5 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.203 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.203 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.203 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.203 | 1 | 0.5 |
Trypanosoma brucei | prostaglandin f synthase | 0.203 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.203 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.203 | 1 | 0.5 |
Onchocerca volvulus | 0.203 | 1 | 0.5 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.203 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.203 | 1 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.203 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.203 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.203 | 1 | 1 |
Onchocerca volvulus | 0.203 | 1 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.203 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.203 | 1 | 0.5 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.203 | 1 | 0.5 |
Schistosoma mansoni | pol-related | 0.203 | 1 | 0.5 |
Toxoplasma gondii | aldose reductase, putative | 0.203 | 1 | 0.5 |
Giardia lamblia | Aldose reductase | 0.203 | 1 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.203 | 1 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.203 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.203 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.203 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.203 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.203 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.203 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.203 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.203 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IA (functional) | Agonist activity on Gal4 chimeric human Peroxisome proliferator activated receptor delta expressed in CHO-K1 cells | ChEMBL. | 12904063 | |
IA (functional) | Agonist activity on Gal4 chimeric human Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells | ChEMBL. | 12904063 | |
IA (functional) | In vitro effective concentration for agonist activity on human Peroxisome proliferator activated receptor gamma-Gal4 chimeric receptor in transfected CHO-K1 cells at 10 microM | ChEMBL. | 12904063 | |
IA (functional) | 0 | Agonist activity on Gal4 chimeric human Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells | ChEMBL. | 12904063 |
IA (functional) | 0 | In vitro effective concentration for agonist activity on human Peroxisome proliferator activated receptor gamma-Gal4 chimeric receptor in transfected CHO-K1 cells at 10 microM | ChEMBL. | 12904063 |
IA (functional) | 0 | Agonist activity on Gal4 chimeric human Peroxisome proliferator activated receptor delta expressed in CHO-K1 cells | ChEMBL. | 12904063 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.