Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.2599 | 1 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.2599 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2599 | 1 | 0.5 |
Onchocerca volvulus | 0.2599 | 1 | 0.5 | |
Echinococcus multilocularis | aldo keto reductase | 0.2599 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2599 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.2599 | 1 | 0.5 |
Giardia lamblia | Aldose reductase | 0.2599 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2599 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2599 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2599 | 1 | 1 |
Leishmania major | prostaglandin f synthase, putative | 0.2599 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.2599 | 1 | 0.5 |
Leishmania major | aldo-keto reductase-like protein | 0.2599 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2599 | 1 | 1 |
Onchocerca volvulus | 0.2599 | 1 | 0.5 | |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.2599 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.2599 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2599 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2599 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.2599 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.2599 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.2599 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2599 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2599 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2599 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2599 | 1 | 1 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.2599 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.2599 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.2599 | 1 | 0.5 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.2599 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.2599 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2599 | 1 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.2599 | 1 | 0.5 |
Mycobacterium ulcerans | oxidoreductase | 0.2599 | 1 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.2599 | 1 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.2599 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2599 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.2599 | 1 | 0.5 |
Onchocerca volvulus | 0.2599 | 1 | 0.5 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2599 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.2599 | 1 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.2599 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2599 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2599 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.2599 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2599 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2599 | 1 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.2599 | 1 | 0.5 |
Onchocerca volvulus | 0.2599 | 1 | 0.5 | |
Loa Loa (eye worm) | oxidoreductase | 0.2599 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2599 | 1 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.2599 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2599 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.2599 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2599 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2599 | 1 | 1 |
Trypanosoma brucei | prostaglandin f synthase | 0.2599 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2599 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2599 | 1 | 1 |
Trypanosoma cruzi | aldo-keto reductase | 0.2599 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.2599 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.2599 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2599 | 1 | 1 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.2599 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2599 | 1 | 0.5 |
Toxoplasma gondii | aldose reductase, putative | 0.2599 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.2599 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.2599 | 1 | 1 |
Onchocerca volvulus | 0.2599 | 1 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2599 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2599 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.2599 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2599 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2599 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.2599 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2599 | 1 | 0.5 |
Onchocerca volvulus | 0.2599 | 1 | 0.5 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2599 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.2599 | 1 | 1 |
Schistosoma mansoni | pol-related | 0.2599 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 8.1 % | Percentage of inhibition of Prostaglandin G/H synthase 1 activity in human whole blood (HWB) at 10 microM | ChEMBL. | 11462976 |
Inhibition (binding) | = 8.1 % | Percentage of inhibition of Prostaglandin G/H synthase 1 activity in human whole blood (HWB) at 10 microM | ChEMBL. | 11462976 |
Inhibition (binding) | = 21.9 % | Percentage inhibition of Prostaglandin G/H synthase 2 activity in human whole blood (HWB) at 10 microM | ChEMBL. | 11462976 |
Inhibition (binding) | = 21.9 % | Percentage inhibition of Prostaglandin G/H synthase 2 activity in human whole blood (HWB) at 10 microM | ChEMBL. | 11462976 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.