Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.0154 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.0073 | 0.3529 | 0.5 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0073 | 0.3529 | 1 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0073 | 0.3529 | 0.5 |
Treponema pallidum | thymidylate kinase (tmk) | 0.0073 | 0.3529 | 0.5 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.0073 | 0.3529 | 0.5 |
Entamoeba histolytica | Thymidylate kinase, putative | 0.0073 | 0.3529 | 0.5 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.0154 | 1 | 1 |
Mycobacterium ulcerans | thymidylate kinase | 0.0073 | 0.3529 | 0.5 |
Toxoplasma gondii | thymidylate kinase | 0.0073 | 0.3529 | 0.5 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0154 | 1 | 1 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0073 | 0.3529 | 1 |
Mycobacterium leprae | probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) | 0.0073 | 0.3529 | 0.5 |
Mycobacterium tuberculosis | Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) | 0.0073 | 0.3529 | 0.5 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.0154 | 1 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0154 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0154 | 1 | 1 |
Plasmodium vivax | thymidylate kinase, putative | 0.0073 | 0.3529 | 0.5 |
Plasmodium falciparum | thymidylate kinase | 0.0073 | 0.3529 | 0.5 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.0154 | 1 | 1 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.0073 | 0.3529 | 0.5 |
Giardia lamblia | CDC8 | 0.0073 | 0.3529 | 0.5 |
Leishmania major | thymidylate kinase-like protein | 0.0073 | 0.3529 | 1 |
Chlamydia trachomatis | thymidylate kinase | 0.0073 | 0.3529 | 0.5 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0073 | 0.3529 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 93.06 ug ml-1 | Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay | ChEMBL. | 26299348 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.