Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | peroxisome proliferator-activated receptor gamma | Starlite/ChEMBL | References |
Homo sapiens | RAR-related orphan receptor C | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | ecdysone induced protein 78C | peroxisome proliferator-activated receptor gamma | 477 aa | 447 aa | 28.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0021 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0021 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0021 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0021 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0021 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0021 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0021 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0021 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0021 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0021 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0021 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0021 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0021 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0021 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0021 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0021 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0021 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0021 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0021 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0021 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0021 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0021 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0021 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0021 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0021 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0021 | 0.5 | 0.5 | |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0021 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0021 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0021 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0021 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0021 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0021 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0021 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0021 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0021 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0021 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0021 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0021 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0021 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0021 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0021 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0021 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0021 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0021 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0021 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0021 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0021 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0021 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0021 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0021 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0021 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0021 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0021 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0021 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0021 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0021 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0021 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0021 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0021 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0021 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0021 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0021 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 0.016 uM | Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed as inhibition of SRC1 co-activator peptide recruitment after 3 hrs by TR-FRET analysis | ChEMBL. | 26048793 |
Efficacy (binding) | = -99 % | Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed as inhibition of SRC1 co-activator peptide recruitment after 3 hrs by TR-FRET analysis relative to apo-RORc ligand binding domain | ChEMBL. | 26048793 |
IC50 (binding) | = 0.13 uM | Displacement of fluormone PPARgamma green from GST-tagged human PPARgamma-LBD after 2 hrs by fluorescence polarization assay | ChEMBL. | 26048793 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.