Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0059 | 0.0755 | 0.0755 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0451 | 1 | 1 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0451 | 1 | 1 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0059 | 0.0755 | 0.0755 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0621 | 0.0621 |
Onchocerca volvulus | 0.0059 | 0.0755 | 0.0755 | |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0059 | 0.0755 | 0.5 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0451 | 1 | 1 |
Toxoplasma gondii | kringle domain-containing protein | 0.0059 | 0.0755 | 1 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0451 | 1 | 1 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0034 | 0.0182 | 0.0182 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0034 | 0.0182 | 0.0182 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0059 | 0.0755 | 0.0755 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0451 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0059 | 0.0755 | 0.5 |
Brugia malayi | Kringle domain containing protein | 0.0059 | 0.0755 | 0.0755 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0034 | 0.0182 | 0.0182 |
Echinococcus granulosus | Tolloid protein 1 | 0.0034 | 0.0182 | 0.0182 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0182 | 0.0182 |
Leishmania major | hypothetical protein, conserved | 0.0059 | 0.0755 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0755 | 0.0755 |
Schistosoma mansoni | hypothetical protein | 0.0059 | 0.0755 | 0.0755 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0059 | 0.0755 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0059 | 0.0755 | 0.0755 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 100 uM | Tested in vitro for anticancer activity against replication of murine leukemia L1210 cell line after 72 h incubation | ChEMBL. | 8381182 |
ED50 (functional) | > 100 uM | Tested in vitro for anticancer activity against replication of murine leukemia P388 cell line after 72 h incubation | ChEMBL. | 8381182 |
ED50 (functional) | > 100 uM | Tested in vitro for anticancer activity against replication of murine Sarcoma 180 cell line after 72 h incubation | ChEMBL. | 8381182 |
ED50 (functional) | > 100 uM | Tested in vitro for anticancer activity against replication of human CCRF-CEM lymphoblastic cell line after 72 h incubation | ChEMBL. | 8381182 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.