Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adenosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania infantum | adenosine kinase-like protein | Adenosine kinase | 361 aa | 351 aa | 37.6 % |
Leishmania donovani | adenosine kinase-like protein | Adenosine kinase | 361 aa | 351 aa | 37.6 % |
Candida albicans | similar to Ribokinase | Adenosine kinase | 361 aa | 303 aa | 21.5 % |
Candida albicans | similar to Ribokinase | Adenosine kinase | 361 aa | 309 aa | 20.7 % |
Leishmania major | adenosine kinase-like protein | Adenosine kinase | 361 aa | 351 aa | 36.8 % |
Leishmania mexicana | adenosine kinase-like protein | Adenosine kinase | 361 aa | 344 aa | 36.6 % |
Leishmania braziliensis | adenosine kinase-like protein | Adenosine kinase | 361 aa | 351 aa | 37.6 % |
Schistosoma mansoni | ribokinase | Adenosine kinase | 361 aa | 289 aa | 23.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.1168 | 1 | 1 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.1168 | 1 | 1 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.043 | 0.3129 | 0.3052 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.1168 | 1 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.043 | 0.3129 | 1 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.1168 | 1 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.043 | 0.3129 | 1 |
Toxoplasma gondii | kinase, pfkB family protein | 0.0105 | 0.0111 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.043 | 0.3129 | 0.3052 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 0.1176 | 0.1077 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.1168 | 1 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.043 | 0.3129 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 90 nM | Evaluated in vitro for inhibitory activity against Adenosine kinase (AK) | ChEMBL. | 12166937 |
IC50 (binding) | = 90 nM | Evaluated in vitro for inhibitory activity against Adenosine kinase (AK) | ChEMBL. | 12166937 |
IC50 (functional) | = 515 nM | Evaluated in vitro for the inhibition of Adenosine (ADO) phosphorylation in intact cells. | ChEMBL. | 12166937 |
IC50 (functional) | = 515 nM | Evaluated in vitro for the inhibition of Adenosine (ADO) phosphorylation in intact cells. | ChEMBL. | 12166937 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 12166937 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.