Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | bromodomain containing | 0.0318 | 0.0462 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0511 | 1 | 0.5 |
Echinococcus granulosus | Bromodomain containing protein | 0.049 | 0.8935 | 1 |
Echinococcus multilocularis | Bromodomain containing protein | 0.049 | 0.8935 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = -27.8 % | Antiobesity activity in lean normal BALB/c mouse assessed as change in average daily food intake at 0.62 mmol/kg/day administered through diet for 7 days relative to time-matched control | ChEMBL. | 19422230 |
Activity (functional) | = -26.8 % | Antiobesity activity in ob/ob mouse model assessed as change in average daily food intake at 0.27 mmol/kg/day administered through diet for 28 days relative to time-matched control | ChEMBL. | 19422230 |
Activity (functional) | = -14.7 % | Antiobesity activity in lean normal BALB/c mouse assessed as change in average daily weight at 0.62 mmol/kg/day administered through diet for 7 days relative to time-matched control | ChEMBL. | 19422230 |
Activity (functional) | = -9.8 % | Antiobesity activity in high fat diet-induced obese BALB/c mouse model assessed as change in average daily food intake at 0.45 mmol/kg/day administered through diet for 28 days relative to time-matched control | ChEMBL. | 19422230 |
Activity (functional) | = -8.7 % | Antiobesity activity in ob/ob mouse model assessed as change in average daily weight at 0.27 mmol/kg/day administered through diet for 28 days relative to time-matched control | ChEMBL. | 19422230 |
Activity (functional) | = -7.8 % | Antiobesity activity in high fat diet-induced obese BALB/c mouse model assessed as change in average daily body weight at 0.45 mmol/kg/day administered through diet for 28 days relative to time-matched control | ChEMBL. | 19422230 |
Activity (functional) | = 56 % | Hypoglycemic activity in lean normal BALB/c mouse assessed as blood glucose level at 0.62 mmol/kg/day administered through diet for 7 days relative to time-matched control | ChEMBL. | 19422230 |
Activity (functional) | = 93 % | Hypoglycemic activity in high fat diet-induced obese BALB/c mouse model assessed as blood glucose level at 0.45 mmol/kg/day administered through diet for 28 days relative to time-matched control | ChEMBL. | 19422230 |
Activity (functional) | = 102 % | Hypoglycemic activity in ob/ob mouse model assessed as blood glucose level at 0.27 mmol/kg/day administered through diet for 28 days relative to time-matched control | ChEMBL. | 19422230 |
ID/g (ADMET) | = 5.9 % | Tissue distribution expressed as percentage injected dose per gram of tissue in normal mice adrenals after 1 hour | ChEMBL. | 7932592 |
ID/g (ADMET) | = 5.9 % | Tissue distribution expressed as percentage injected dose per gram of tissue in normal mice adrenals after 1 hour | ChEMBL. | 7932592 |
ID/g (ADMET) | = 9.7 % | tissue distribution expressed as percentage injected dose per gram of tissue in normal mice heart after 1 hour | ChEMBL. | 7932592 |
ID/g (ADMET) | = 9.7 % | tissue distribution expressed as percentage injected dose per gram of tissue in normal mice heart after 1 hour | ChEMBL. | 7932592 |
ID/g (ADMET) | = 15.3 % | Tissue distribution expressed as percentage injected dose per gram of tissue in normal mice heart after 4 hour | ChEMBL. | 7932592 |
ID/g (ADMET) | = 15.3 % | Tissue distribution expressed as percentage injected dose per gram of tissue in normal mice heart after 4 hour | ChEMBL. | 7932592 |
ID/g (ADMET) | = 20.3 % | Tissue distribution expressed as percentage injected dose per gram of tissue in normal mice adrenals after 4 hour | ChEMBL. | 7932592 |
ID/g (ADMET) | = 20.3 % | Tissue distribution expressed as percentage injected dose per gram of tissue in normal mice adrenals after 4 hour | ChEMBL. | 7932592 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.