Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | nitric oxide synthase 2, inducible | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0029 | 0.7709 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0032 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0032 | 1 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0032 | 1 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0032 | 1 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0032 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0032 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0032 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0032 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0032 | 1 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0032 | 1 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0032 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0032 | 1 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0029 | 0.7709 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0032 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0032 | 1 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.002 | 0.2291 | 0.2291 |
Chlamydia trachomatis | sulfite reductase | 0.002 | 0.2291 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0032 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0032 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0032 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0032 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0032 | 1 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0032 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0032 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 200 nM | Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of nitric oxide production after 48 hrs by Griess assay | ChEMBL. | 25965897 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.