Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0303 | 0.1689 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.1482 | 1 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.1797 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0028 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.1797 | 1 |
Mycobacterium tuberculosis | Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. | 0.083 | 1 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0028 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0347 | 0.398 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0028 | 0 | 0.5 |
Mycobacterium ulcerans | proteasome PrcA | 0.083 | 1 | 0.5 |
Echinococcus multilocularis | geminin | 0.0172 | 0.1797 | 1 |
Echinococcus granulosus | geminin | 0.0172 | 0.1797 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 34.8 % | Inhibition of STS activity in human MCF7 cells at 0.1 uM for 20 hrs in presence of [3H]estrone sulfate | ChEMBL. | 25992880 |
Inhibition (binding) | = 62.1 % | Inhibition of STS activity in human placental microsome at 10 uM in presence of [3H]-estrone sulfate | ChEMBL. | 25992880 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.